User profiles for Koichi Sugimoto

Koichi Sugimoto

University of Tsukuba
Verified email at u.tsukuba.ac.jp
Cited by 1684

Modulation of microRNA processing by p53

HI Suzuki, K Yamagata, K Sugimoto, T Iwamoto, S Kato… - Nature, 2009 - nature.com
MicroRNAs (miRNAs) have emerged as key post-transcriptional regulators of gene expression,
involved in diverse physiological and pathological processes. Although miRNAs can …

Selective apoptosis of natural killer‐cell tumours by l‐asparaginase

M Ando, K Sugimoto, T Kitoh, M Sasaki… - British journal of …, 2005 - Wiley Online Library
We examined the effectiveness of various anti‐tumour agents to natural killer (NK)‐cell
tumour cell lines and samples, which are generally resistant to chemotherapy, using flow …

Autophagy is activated by TGF-β and potentiates TGF-β–mediated growth inhibition in human hepatocellular carcinoma cells

…, Y Morishita, A Komuro, MR Kano, K Sugimoto… - Cancer research, 2009 - AACR
Transforming growth factor-β (TGF-β) is a multifunctional cytokine that regulates cell growth,
differentiation, and apoptosis of various types of cells. Autophagy is emerging as a critical …

[PDF][PDF] MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation

…, H Matsuyama, YL Choi, T Ueno, H Mano, K Sugimoto… - Molecular cell, 2011 - cell.com
MicroRNAs (miRNAs) are versatile regulators of gene expression and undergo complex
maturation processes. However, the mechanism(s) stabilizing or reducing these small RNAs …

Frequent mutations in the p53 gene in human myeloid leukemia cell lines

K Sugimoto, H Toyoshima, R Sakai, K Miyagawa… - 1992 - ashpublications.org
The p53 gene is currently considered to function as a tumor-suppressor gene in various
human malignancies. In hematologic malignancies, alterations in the p53 gene have been …

Intake and transformation to a glycoside of (Z)-3-hexenol from infested neighbors reveals a mode of plant odor reception and defense

K Sugimoto, K Matsui, Y Iijima… - Proceedings of the …, 2014 - National Acad Sciences
Plants receive volatile compounds emitted by neighboring plants that are infested by
herbivores, and consequently the receiver plants begin to defend against forthcoming herbivory. …

miR-135b mediates NPM-ALK–driven oncogenicity and renders IL-17–producing immunophenotype to anaplastic large cell lymphoma

…, N Komatsu, H Mano, K Sugimoto… - Blood, The Journal …, 2011 - ashpublications.org
Many transformed lymphoma cells show immune-phenotypes resembling the corresponding
normal lymphocytes; thus, they provide a guide for proper diagnosis and present promising …

Regulation of growth–defense balance by the JASMONATE ZIM‐DOMAIN (JAZ)‐MYC transcriptional module

…, ML Campos, G Kapali, XF Xin, K Sugimoto… - New …, 2017 - Wiley Online Library
The plant hormone jasmonate ( JA ) promotes the degradation of JASMONATE ZIM‐DOMAIN
( JAZ ) proteins to relieve repression on diverse transcription factors (TFs) that execute JA …

JAZ repressors of metabolic defense promote growth and reproductive fitness in Arabidopsis

…, IT Major, K Wang, K Sugimoto… - Proceedings of the …, 2018 - National Acad Sciences
Plant immune responses mediated by the hormone jasmonoyl-l-isoleucine (JA-Ile) are
metabolically costly and often linked to reduced growth. Although it is known that JA-Ile activates …

P-glycoprotein expression on normal and abnormally expanded natural killer cells and inhibition of P-glycoprotein function by cyclosporin A and its analogue, PSC833

M Egashira, N Kawamata, K Sugimoto… - Blood, The Journal …, 1999 - ashpublications.org
P-glycoprotein (P-gp), a transmembrane efflux pump encoded by theMDR1 gene, has been
found to be expressed in many normal bone marrow and peripheral blood cells. Among …