[HTML][HTML] Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy

KM Mahadeo, SJ Khazal, H Abdel-Azim… - Nature Reviews …, 2019 - nature.com
In 2017, an autologous chimeric antigen receptor (CAR) T cell therapy indicated for children
and young adults with relapsed and/or refractory CD19 + acute lymphoblastic leukaemia …

[HTML][HTML] Autologous CD33-CAR-T cells for treatment of relapsed/refractory acute myelogenous leukemia

…, H Singh, E Jones, M Rytting, KM Mahadeo… - Leukemia, 2021 - nature.com
Acute myelogenous leukemia (AML) is a potentially curable disease; 70% of newly diagnosed
patients achieve complete remission with first-line therapy, but prognosis worsens for …

[HTML][HTML] Immune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome

…, MD Jain, WT Johnson, Y Lin, KM Mahadeo… - … and Cellular Therapy, 2023 - Elsevier
Background T cell mediated hyperinflammatory responses such as cytokine release syndrome
(CRS) and immune effector cell associated neurotoxicity syndrome (ICANS) are now well-…

A pragmatic multi-institutional approach to understanding transplant-associated thrombotic microangiopathy after stem cell transplant

…, KM Mahadeo, S Khazal, N Lalefar, M Vissa… - Blood …, 2021 - ashpublications.org
Transplant-associated thrombotic microangiopathy (TA-TMA) is a severe complication of
hematopoietic stem cell transplantation (HSCT). A single-center prospective screening study …

[HTML][HTML] Blastic plasmacytoid dendritic cell neoplasm: a comprehensive review in pediatrics, adolescents, and young adults (AYA) and an update of novel therapies

…, D Petropoulos, P Tewari, C Nunez, KM Mahadeo… - Leukemia, 2023 - nature.com
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy that
can involve the bone marrow, peripheral blood, skin, lymph nodes, and the central nervous …

[HTML][HTML] Venetoclax for children and adolescents with acute lymphoblastic leukemia and lymphoblastic lymphoma

…, S Khazal, L Toepfer, DH Bell, M Roth, KM Mahadeo… - Cancers, 2021 - mdpi.com
Simple Summary Pediatric patients with relapsed or refractory acute lymphoblastic leukemia
(ALL) or lymphoma (LBL) currently have unsatisfactory outcomes, and novel treatment …

Invasive mechanical ventilation and mortality in pediatric hematopoietic stem cell transplantation: a multicenter study

…, DD Hsing, CN Duncan, KM Mahadeo… - Pediatric Critical Care …, 2016 - journals.lww.com
Objective: To establish the current respiratory practice patterns in pediatric hematopoietic
stem cell transplant patients and investigate their associations with mortality across multiple …

Diagnosis, grading, and treatment recommendations for children, adolescents, and young adults with sinusoidal obstructive syndrome: an international expert position …

KM Mahadeo, R Bajwa, H Abdel-Azim… - The Lancet …, 2020 - thelancet.com
Sinusoidal obstructive syndrome, also known as hepatic veno-occlusive disease, is a potentially
life-threatening complication that occurs in children undergoing haemopoietic stem-cell …

Extracorporeal membrane oxygenation in adults receiving haematopoietic cell transplantation: an international expert statement

…, R Lorusso, A Amodeo, KM Mahadeo… - The Lancet …, 2023 - thelancet.com
Combined advances in haematopoietic cell transplantation (HCT) and intensive care
management have improved the survival of patients with haematological malignancies admitted to …

[HTML][HTML] Humoral immune reconstitution kinetics after allogeneic hematopoietic stem cell transplantation in children: a maturation block of IgM memory B cells may …

H Abdel-Azim, A Elshoury, KM Mahadeo… - Biology of Blood and …, 2017 - Elsevier
Although T cell immune reconstitution after allogeneic hematopoietic stem cell transplantation
(allo-HSCT) has been well studied, long-term B cell immune reconstitution remains less …