DALI: defining antibiotic levels in intensive care unit patients: are current β-lactam antibiotic doses sufficient for critically ill patients?

…, E Meyer, F Del Nogal, L Vidaur… - Clinical infectious …, 2014 - academic.oup.com
Background. Morbidity and mortality for critically ill patients with infections remains a global
healthcare problem. We aimed to determine whether β-lactam antibiotic dosing in critically ill …

[HTML][HTML] Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1) v in Spain

…, E Maraví-Poma, P Albert, R Sierra, L Vidaur… - Critical care, 2009 - Springer
… 498.4 U/L and alanine aminotransferase = 156.1 ± 336.2 U/L) and twenty-six patients (81.2%)
had increased (mean 2100 ± 34311 U/L) creatinine kinase levels (range 226 to 3047 U/L). …

Autoantibodies neutralizing type I IFNs are present in~ 4% of uninfected individuals over 70 years old and account for~ 20% of COVID-19 deaths

…, O Boyarchuk, Y Nukui, M Tsumura, L Vidaur… - Science …, 2021 - science.org
Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma
diluted 1:10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID-19 …

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

…, Y Nukui, M Tsumura, L Vidaur… - Proceedings of the …, 2022 - National Acad Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR)
doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing …

De-escalation therapy in ventilator-associated pneumonia

J Rello, L Vidaur, A Sandiumenge… - Critical care …, 2004 - journals.lww.com
… Heyland DK, Cook DJ, Griffith L, et al: The attributable morbidity and mortality of ventilator-associated
pneumonia in the critically ill patient. The Canadian Critical Trials Group. Am J …

Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient …

…, E Meyer, F Del Nogal, L Vidaur… - Journal of …, 2016 - academic.oup.com
Objectives We utilized the database of the Defining Antibiotic Levels in Intensive care unit
patients (DALI) study to statistically compare the pharmacokinetic/pharmacodynamic and …

Impact of diversity of antibiotic use on the development of antimicrobial resistance

…, A Rodriguez, L Vidaur, L Canadell… - Journal of …, 2006 - academic.oup.com
Objectives: To evaluate the impact of different antibiotic strategies on acquisition of resistant
microorganisms. Methods: A prospective study was conducted over a 44 month period in a …

Procalcitonin (PCT) levels for ruling-out bacterial coinfection in ICU patients with influenza: a CHAID decision-tree analysis

…, SI Trefler, J Solé-Violán, L Cordero, L Vidaur… - Journal of infection, 2016 - Elsevier
… The analytical sensitivity of all assays was <0·05 μg/L. All techniques were based on a
one-step immunoassay sandwich method determined either by chemiluminescence or …

[HTML][HTML] Early non-invasive ventilation treatment for severe influenza pneumonia

…, L Lorente, A Marques, L Socias, L Vidaur… - Clinical Microbiology …, 2013 - Elsevier
The role of non-invasive ventilation (NIV) in acute respiratory failure caused by viral pneumonia
remains controversial. Our objective was to evaluate the use of NIV in a cohort of (H1N1)…

Clinical approach to the patient with suspected ventilator-associated pneumonia

L Vidaur, G Sirgo, AH Rodríguez, J Rello - Respiratory care, 2005 - rc.rcjournal.com
Management of ventilator-associated pneumonia needs to balance the avoidance of
unnecessary antibiotic overuse with the provision of adequate initial empiric therapy. A clinical …