METHODS Search Strategy Pertinent studies were independently searched in BioMedCentral,
PubMed, EMBASE, and the Cochrane Central Register of clinical trials (updated April 15, …

Objective: Noninvasive ventilation is increasingly applied to prevent or treat acute respiratory
failure, but its benefit on survival is still controversial for many indications. We performed a …

Background There is substantial variability in the perioperative administration of aspirin in
patients undergoing noncardiac surgery, both among patients who are already on an aspirin …

Background Marked activation of the sympathetic nervous system occurs during and after
noncardiac surgery. Low-dose clonidine, which blunts central sympathetic outflow, may …

Objectives Delirium frequently is observed in critically ill patients in the intensive care unit (ICU)
and is associated strongly with a poor outcome. Dexmedetomidine seems to reduce time …

Objectives Efficacy and safety of corticosteroids in patients with 2019-nCoV (novel coronavirus
2019) infection still are debated. Because large randomized clinical trials (RCTs) and a …

OBJECTIVE: With more than 220 million major surgical procedures performed annually,
perioperative interventions leading to even minor mortality reductions would save thousands of …

Introduction The preoperative period is a stressing occurrence for most people undergoing
surgery, in particular children. Approximately 50–75% of children undergoing surgery …

Rationale: The “Berlin definition” of acute respiratory distress syndrome (ARDS) does not
allow inclusion of patients receiving high-flow nasal oxygen (HFNO). However, several articles …

Importance Acute kidney injury, a common complication of surgery, is associated with poor
outcomes and high health care costs. Some studies suggest aspirin or clonidine …