Worldwide, billions of dollars are invested in medical product development and there is an
increasing pressure to maximize the revenues of these investments. That is, governments …

Introduction. Many cancer survivors suffer from a combination of disease- and treatment-related
morbidities and complaints after primary treatment. There is a growing evidence base for …

Objective To support decision making on how to best redesign chronic care by studying the
heterogeneity in effectiveness across chronic care management evaluations for heart failure. …

Aims: To describe the distribution of COPD disease severity in primary care based on airway
obstruction, and to assess the extent to which dyspnoea scores, body mass index (BMI) and …

Purpose The study aims to support decision making on how best to redesign diabetes care
by investigating three potential sources of heterogeneity in effectiveness across trials of …

Objectives: Medical device companies are under growing pressure to provide health-economic
evaluations of their products. Cost-effectiveness analyses are commonly undertaken as …

Objective: Procalcitonin (PCT) is a specific marker for differentiating bacterial from non-infective
causes of inflammation. It can be used to guide initiation and duration of antibiotic …

Objective To identify the most appropriate generic instrument to measure experience and/or
satisfaction of people receiving integrated chronic care. Background Health care is …

Purpose Whole-gland salvage for recurrent prostate cancer (PCa) shows high failure and
toxicity rates. Early and adequate localization of recurrences enables focal salvage, thereby …

Rationale, aims and objectives Clinical diversity and methodological heterogeneity exists
between studies on chronic care management. This study aimed to examine the effectiveness …