Valosin-containing protein (p97) is a regulator of endoplasmic reticulum stress and of the degradation of N-end rule and ubiquitin-fusion degradation pathway …

…, D Nowis, E McConnell, M Kujawa… - Molecular biology of …, 2006 - Am Soc Cell Biol
Valosin-containing protein (VCP; p97; cdc48 in yeast) is a hexameric ATPase of the AAA family
(ATPases with multiple cellular activities) involved in multiple cellular functions, including …

[HTML][HTML] Cardiotoxicity of the anticancer therapeutic agent bortezomib

…, M Mączewski, U Mackiewicz, M Kujawa… - The American journal of …, 2010 - Elsevier
Recent case reports provided alarming signals that treatment with bortezomib might be
associated with cardiac events. In all reported cases, patients experiencing cardiac problems …

Proteasome inhibition potentiates antitumor effects of photodynamic therapy in mice through induction of endoplasmic reticulum stress and unfolded protein response

…, M Makowski, D Nowis, GM Wilczynski, M Kujawa… - Cancer research, 2009 - AACR
Photodynamic therapy (PDT) is an approved therapeutic procedure that exerts cytotoxic
activity toward tumor cells by inducing production of reactive oxygen species such as singlet …

Hoc protein regulates the biological effects of T4 phage in mammals

…, J Wietrzyk, A Opolski, K Szczaurska, M Kujawa… - Archives of …, 2007 - Springer
We previously investigated the biological, non-antibacterial effects of bacteriophage T4 in
mammals (binding to cancer cells in vitro and attenuating tumour growth and metastases in …

SK053 triggers tumor cells apoptosis by oxidative stress-mediated endoplasmic reticulum stress

…, M Firczuk, M Wachowska, M Kujawa… - Biochemical …, 2015 - Elsevier
Thioredoxins (Trx) together with thioredoxin reductases (TrxR) participate in the maintenance
of protein thiol homeostasis and play cytoprotective roles in tumor cells. Therefore, …

Decreased ER-associated degradation of α-TCR induced by Grp78 depletion with the SubAB cytotoxin

A Lass, M Kujawa, E McConnell, AW Paton… - The international journal …, 2008 - Elsevier
HeLa cells stably expressing the α chain of T-cell receptor (αTCR), a model substrate of ER-associated
degradation (ERAD), were used to analyze the effects of BiP/Grp78 depletion by …

Fine structure of the zona pellucida of unfertilized egg cells and embryos

…, M Konwiński, M Kujawa - Journal of Experimental …, 1975 - Wiley Online Library
The fine structure of the zona pellucida of mouse unfertilized egg cells and of mouse embryos
was investigated. In addition to standard fixation for electron microscopy, fixation with an …

Temporal/spatial expression and efflux activity of ABC transporter, P-glycoprotein/Abcb1 isoforms and Bcrp/Abcg2 during early murine development

WT Sawicki, M Kujawa, E Jankowska-Steifer… - Gene expression …, 2006 - Elsevier
ABC transporters pump out from cells a large number of endo- and xenobiotics including
signal molecules and toxins; they are molecular markers of stem/progenitor cells as well. Here, …

Comparison of airway wall remodeling in asthma and COPD: biopsy findings

…, R Krenke, K Gorska, W Baran, M Kujawa… - Respiratory …, 2012 - rc.rcjournal.com
BACKGROUND: Bronchial remodeling is currently known to affect not only patients with
asthma, but also COPD patients. Some studies have demonstrated that basement membrane …

Quantitative ultrastructural changes in satellite cells of rats immobilized after soleus muscle denervation

M Kujawa, W Baran, E Jankowska-Steifer - Experimental and molecular …, 2005 - Elsevier
Quantitative ultrastructural evaluation of satellite cells (SCs) of rats immobilized for 7, 14, and
36 days after soleus muscle denervation was performed. Alterations in SCs of experimental …