Cascade impactors for the size characterization of aerosols from medical inhalers: their uses and limitations

JP Mitchell, MW Nagel - Journal of aerosol medicine, 2003 - liebertpub.com
Cascade impactors, including the multi-stage liquid impinger, are by far the most widely
encountered means for the in vitro determination of the particle size distribution of aerosols from …

Aerodynamic particle size analysis of aerosols from pressurized metered-dose inhalers: comparison of Andersen 8-stage cascade impactor, next generation …

JP Mitchell, MW Nagel, KJ Wiersema, CC Doyle - AAPS PharmSciTech, 2003 - Springer
The purpose of this research was to compare three different methods for the aerodynamic
assessment of (1) chloroflurocarbon (CFC)-fluticasone propionate (Flovent), (2) CFC-sodium …

Laser diffractometry as a technique for the rapid assessment of aerosol particle size from inhalers

JP Mitchell, MW Nagel, S Nichols… - Journal of aerosol …, 2006 - liebertpub.com
The rapid assessment of aerosols produced by medicinal inhalers is highly desirable from
several standpoints, including the assurance of product quality, the development of new …

Valved holding chambers (VHCs) for use with pressurised metered-dose inhalers (pMDIs): a review of causes of inconsistent medication delivery

JP Mitchell, MW Nagel - Primary Care Respiratory Journal, 2007 - nature.com
Background: Valved holding chambers (VHCs) are prescribed with pressurised metered-dose
inhalers (pMDIs) to improve medication delivery for the treatment of respiratory diseases …

Electrostatics and inhaled medications: influence on delivery via pressurized metered-dose inhalers and add-on devices

JP Mitchell, DP Coppolo, MW Nagel - Respiratory care, 2007 - rc.rcjournal.com
The movement of inhaler-generated aerosols is significantly influenced by electrostatic
charge on the particles and on adjacent surfaces. Particle charging arises in the aerosol …

Time-of-flight aerodynamic particle size analyzers: their use and limitations for the evaluation of medical aerosols

JP MITCHELL, MW NAGEL - Journal of aerosol medicine, 1999 - liebertpub.com
Time-of-flight (TOF) aerosol analyzers are a class of instruments that measure the aerodynamic
diameter of individual particles following a controlled acceleration in a well-defined flow …

Relative precision of inhaler aerodynamic particle size distribution (APSD) metrics by full resolution and abbreviated Andersen cascade impactors (ACIs): part 1

JP Mitchell, MW Nagel, CC Doyle, RS Ali… - Aaps Pharmscitech, 2010 - Springer
The purpose of this study was to compare relative precision of two different abbreviated
impactor measurement (AIM) systems and a traditional multi-stage cascade impactor (CI). The …

The importance of nonelectrostatic materials in holding chambers for delivery of hydrofluoroalkane albuterol

JL Rau, DP Coppolo, MW Nagel… - Respiratory …, 2006 - rc.rcjournal.com
INTRODUCTION: Electrostaticattraction of aerosolized particles to the inner walls of an
aerosol holding chamber (HC) made from a nonconducting material can reduce medication …

In Vitro Performance Testing of Three Small Volume-Holding Chambers under Conditions That Correspond with Use by Infants and Small Children

JP Mitchell, MW Nagel - Journal of aerosol medicine, 1997 - liebertpub.com
The in vitro behavior of three types of small volume-holding chambers intended for use by
infants and small children (child AeroChamber®, Vent-170 and Space Chamber™) has been …

Performance of large-and small-volume valved holding chambers with a new combination long-term bronchodilator/anti-inflammatory formulation delivered by …

MW Nagel, KJ Wiersema, SL Bates… - Journal of aerosol …, 2002 - liebertpub.com
The treatment of both the bronchoconstriction and inflammatory aspects of asthma simultaneously
by a single pressurized metered dose inhaler (pMDI) represents a significant advance …