Several factors have been recognized as possible triggers of ventilator-induced lung injury (VILI).
The first is pressure (thus the ‘barotrauma’), then the volume (hence the ‘volutrauma’), …

In summary, we found that hypercapnia was common in patients with COVID-19–associated
ARDS while using low VT ventilation. VR was increased in these patients, which reflected …

Background In the acute respiratory distress syndrome (ARDS), positive end-expiratory
pressure (PEEP) may decrease ventilator-induced lung injury by keeping lung regions open that …

Rationale: Lung injury caused by a ventilator results from nonphysiologic lung stress (transpulmonary
pressure) and strain (inflated volume to functional residual capacity ratio). …

Purpose We hypothesized that the ventilator-related causes of lung injury may be unified in
a single variable: the mechanical power. We assessed whether the mechanical power …

When compared, most of the methods give the same positive end-expiratory pressure
values in patients with higher and lower recruitability. The positive end-expiratory pressure/…

Rationale: The effects of high positive end-expiratory pressure (PEEP) strictly depend on
lung recruitability, which varies widely during acute respiratory distress syndrome (ARDS). …

Background The ventilator works mechanically on the lung parenchyma. The authors set
out to obtain the proof of concept that ventilator-induced lung injury (VILI) depends on the …

Rationale: Unphysiologic strain (the ratio between tidal volume and functional residual
capacity) and stress (the transpulmonary pressure) can cause ventilator-induced lung damage. …

Rationale: Pressures and volumes needed to induce ventilator-induced lung injury in healthy
lungs are far greater than those applied in diseased lungs. A possible explanation may be …