Rationale: Several common and rare genetic variants have been associated with idiopathic
pulmonary fibrosis, a progressive fibrotic condition that is localized to the lung. Objectives: …

Background SSc-ILD and IPF demonstrate significant morbidity and mortality. Predicting
disease progression is challenging in both diseases. Objectives We sought a serum biomarker …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a rare, irreversible, and progressive
disease of the lungs. Common genetic variants, in addition to nongenetic factors, have been …

Background Chronic obstructive pulmonary disease (COPD) is a common, preventable, and
treatable respiratory disease. COPD exacerbations are associated with worse quality of life, …

Study objectives Despite the widespread use of short-acting, inhaled β 2 -agonists in acute
exacerbations of COPD (AECOPDs), little is known about their optimal dose. The aims of this …

Background In the investigation of lung cancer, current practice in many healthcare systems
would support bronchoscopy regardless of CT findings in patients with hemoptysis. We …

Lung disease is the direct cause of death in over 90% of cystic fibrosis (CF) patients. Excess
neutrophil elastase is an important determinant of pulmonary disease in CF. α 1-antitrypsin (…

We report the case of a young woman with Crohn's disease of the bowel who presented
with a purulent tracheobronchitis and life-threatening upper airway obstruction. Fibreoptic …

BACKGROUND: Nebulized hypertonic saline is a highly effective therapy for patients with
cystic fibrosis (CF), yet 10% of patients are intolerant of hypertonic saline administered via jet …

Idiopathic pulmonary fibrosis (IPF) is the most common of the idiopathic interstitial pneumonias.
Despite multiple recent clinical trials, there is no strong evidence supporting a survival …