The metabolic rewiring of cardiomyocytes is a widely accepted hallmark of heart failure (HF).
These metabolic changes include a decrease in mitochondrial pyruvate oxidation and an …

… , etc.) were not included in the current analysis (n = 8). By doing so, we eliminated a group
of … HF with preserved systolic function were also excluded (n = 2). The remaining 80 patients …

Cerebral cavernous malformations (CCMs) are a common type of vascular malformation in
the brain that are a major cause of hemorrhagic stroke. This condition has been …

Unlike cardiac and skeletal muscle, little is known about vascular smooth muscle mitochondrial
respiration. Therefore, the present study examined mitochondrial respiratory rates in …

This study sought to investigate the effects of mechanical unloading on myocardial energetics
and the metabolic perturbation of heart failure (HF) in an effort to identify potential new …

Ischemic cardiomyopathy (ICM) is the clinical endpoint of coronary heart disease and a leading
cause of heart failure. Despite growing demands to develop personalized approaches to …

… Next, similar to the analysis of tissue samples, we grouped cells by low (<1 µm, n=8) and
high (>1 µm, n=7) intracellular sarcolemma distance as a measure of high and low t-system …

… (B) Western blot of UBB, ubiquitin conjugates, and UBE2; densitometry analysis is shown
of immunoblot data for UBE2 (n = 23 HF patients, 9 normal donors) (C), UBB (n = 9 heart HF …

Objectives : The purpose of this study was to analyze the effects of left ventricular assist
devices (LVADs) on myocardial sympathetic innervation of the failing heart. Background : …

… Subjects were randomly assigned to aerobic (n= 10) or combined aerobic plus strength
training group (n= 10). Aerobic group performed interval training on cycle ergometers. Strength …