Since interaction between bone and lipid metabolism has been suggested, this study
investigated the regulation of bone metabolism by adiponectin, a representative adipokine, by …

Insulin receptor substrates (IRS-1 and -2) are essential for intracellular signaling by insulin
and IGF-I, anabolic regulators of bone metabolism. Mice lacking the IRS-1 gene IRS-1 –/– …

Bone mass and turnover are maintained by the coordinated balance between bone formation
by osteoblasts and bone resorption by osteoclasts, under regulation of many systemic and …

Because mice deficient in klotho gene expression exhibit multiple aging phenotypes
including osteopenia, we explored the possibility that the klotho gene may contribute to age‐related …

Although accumulated evidence has shown the bone anabolic effects of bone morphogenetic
proteins (BMPs) that were exogenously applied in vitro and in vivo, the roles of …

To better understand the role of the canonical Wnt signaling pathway in cartilage development,
we adenovirally expressed a constitutively active (ca) or a dominant negative (dn) form of …

Stimulatory heterotrimeric G protein (Gs) transduces signals from various cell-surface
receptors to adenylyl cyclases, which generate cAMP. The α subunit of Gs (Gsα) is encoded by …

Insulin receptor substrates (IRS-1 and IRS-2) are essential for intracellular signaling by insulin
and insulin-like growth factor-I (IGF-I), anabolic regulators of bone metabolism. Although …

Background: Glucose intolerance is frequently found in patients with ossification of the
posterior longitudinal ligament of the spine. This study was undertaken to examine the …

cGMP-dependent protein kinase II (cGKII; encoded by PRKG2) is a serine/threonine kinase
that is critical for skeletal growth in mammals; in mice, cGKII deficiency results in dwarfism. …