User profiles for P. Godoy

Patricio Godoy

- Verified email at roche.com - Cited by 6215

Paula Godoy

- Verified email at ucsd.edu - Cited by 713

[HTML][HTML] Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …

P Godoy, NJ Hewitt, U Albrecht, ME Andersen… - Archives of …, 2013 - Springer
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, …

Mechanisms of solvent tolerance in gram-negative bacteria

…, E Duque, MT Gallegos, P Godoy… - Annual Reviews in …, 2002 - annualreviews.org
… Solvents with a log P ow below 4.0, eg, benzene (log P ow 2.13), toluene (log P ow 2.69),
octanol (log P ow 2.92), xylenes (log P ow 3.12–3.2), and styrene (log P ow 2.95), are …

Adverse outcome pathways: opportunities, limitations and open questions

…, B van Ravenzwaay, H Kamp, I Gardner, P Godoy… - Archives of …, 2017 - Springer
Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a
formalized, transparent and quality-controlled way, mechanistic information to apical …

Improvements from a flipped classroom may simply be the fruits of active learning

…, TA Kummer, PDM Godoy - CBE—Life Sciences …, 2015 - Am Soc Cell Biol
The “flipped classroom” is a learning model in which content attainment is shifted forward to
outside of class, then followed by instructor-facilitated concept application activities in class. …

Hepatocyte-specific Smad7 expression attenuates TGF-β–mediated fibrogenesis and protects against liver damage

S Dooley, J Hamzavi, L Ciuclan, P Godoy, I Ilkavets… - Gastroenterology, 2008 - Elsevier
BACKGROUND & AIMS: The profibrogenic role of transforming growth factor (TGF)-β in liver
has mostly been attributed to hepatic stellate cell activation and excess matrix synthesis. …

TGF-β/Smad signaling in the injured liver

K Breitkopf, P Godoy, L Ciuclan… - Zeitschrift für …, 2006 - thieme-connect.com
Direkte und indirekte Wirkmechanismen des Wachstumsfaktors TGF-β stehen im Zentrum
fibrotischer Umbauprozesse in der geschädigten Leber. TGF-β aktiviert hepatische …

Efflux Pumps Involved in Toluene Tolerance in Pseudomonas putida DOT-T1E

JL Ramos, E Duque, P Godoy, A Segura - Journal of bacteriology, 1998 - Am Soc Microbiol
… why a proportion of the P. putida DOT-T1E cells pregrown with toluene in the gas phase
were tolerant to the solvent shock, we tested the survival of P. putida KT2440 pregrown in the …

[HTML][HTML] Mechanisms for solvent tolerance in bacteria

…, E Duque, JJ Rodríguez-Herva, P Godoy… - Journal of Biological …, 1997 - ASBMB
… isolation of three different P. putida strains that tolerated related organic solvents, eg styrene
( … In this study, we have explored the molecular basis for solvent tolerance by P. putida DOT-…

Transposable elements drive widespread expression of oncogenes in human cancers

…, AY Du, ZZ Dailey, EC Pehrsson, PM Godoy… - Nature …, 2019 - nature.com
… We hypothesized that AluJb-P accumulated mutations through evolution that generated
novel transcription factor binding sites that recruit RNAP II. To explore this hypothesis, we …

[PDF][PDF] Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor β–induced apoptosis

P Godoy, JG Hengstler, I Ilkavets, C Meyer… - …, 2009 - Wiley Online Library
… Therefore, we compared TGF-ß induction of pJNK and p-p38 in both culture systems. JNK
activation was constitutively stronger in CM than in CS, and we did not observe any induction …