Background Community transmission of coronavirus 2019 (Covid-19) was detected in the
state of Washington in February 2020. Methods We identified patients from nine Seattle-area …

Chronic kidney disease (CKD) is a common complex condition associated with high
morbidity and mortality. Polygenic prediction could enhance CKD screening and prevention; …

INTRODUCTION Acute kidney injury and chronic kidney disease (CKD) are common in
hospitalized patients. To inform clinical decision making, more accurate information regarding …

Rationale: No direct comparisons of clinical features, laboratory values, and outcomes between
critically ill patients with coronavirus disease (COVID-19) and patients with influenza in …

Rationale: Currently, no safe and effective pharmacologic interventions exist for acute kidney
injury (AKI). One reason may be that heterogeneity exists within the AKI population, thereby …

Importance The severity of acute kidney injury (AKI) is usually determined based on the
maximum serum creatinine concentration. However, the trajectory of kidney function recovery …

Age is a predominant risk factor for acute kidney injury (AKI), yet the biological mechanisms
underlying this risk are largely unknown. Clonal hematopoiesis of indeterminate potential (…

Background Acute kidney injury (AKI) is common among intensive care unit (ICU) patients.
AKI is highly heterogeneous, with variable links to poor outcomes. Current approaches to …

Kidneys are critical target organs of COVID-19, but susceptibility and responses to infection
remain poorly understood. Here, we combine SARS-CoV-2 variants with genome-edited …

Rationale: Serial measurements of alveolar macrophage (AM) transcriptional changes in
patients with acute respiratory distress syndrome (ARDS) could identify cell-specific biological …