Tracheal replacement therapy with a stem cell-seeded graft: lessons from compassionate use application of a GMP-compliant tissue-engineered medicine

…, E Samuel, C Crowley, P Lange… - Stem cells …, 2017 - academic.oup.com
Tracheal replacement for the treatment of end-stage airway disease remains an elusive goal.
The use of tissue-engineered tracheae in compassionate use cases suggests that such an …

[HTML][HTML] The extracellular EXO protein mediates cell expansion in Arabidopsis leaves

F Schröder, J Lisso, P Lange, C Müssig - BMC plant biology, 2009 - Springer
Background The EXO (EXORDIUM) gene was identified as a potential mediator of brassinosteroid
(BR)-promoted growth. It is part of a gene family with eight members in Arabidopsis. …

[HTML][HTML] Preservation of micro-architecture and angiogenic potential in a pulmonary acellular matrix obtained using intermittent intra-tracheal flow of detergent …

…, SP Loukogeorgakis, G Orlando, P Shangaris, P Lange… - Biomaterials, 2013 - Elsevier
Tissue engineering of autologous lung tissue aims to become a therapeutic alternative to
transplantation. Efforts published so far in creating scaffolds have used harsh decellularization …

A comparison of tracheal scaffold strategies for pediatric transplantation in a rabbit model

…, NJ Hamilton, RE Hynds, P Lange… - The …, 2017 - Wiley Online Library
Objectives/Hypothesis Despite surgical advances, childhood tracheal stenosis is associated
with high morbidity and mortality. Various tracheal scaffold strategies have been developed …

Stem cell-based tissue-engineered laryngeal replacement

T Ansari, P Lange, A Southgate, K Greco… - Stem cells …, 2017 - academic.oup.com
Patients with laryngeal disorders may have severe morbidity relating to swallowing,
vocalization, and respiratory function, for which conventional therapies are suboptimal. A tissue-…

Target specificity among canonical nuclear poly (A) polymerases in plants modulates organ growth and pathogen response

SL Vi, G Trost, P Lange, H Czesnick… - Proceedings of the …, 2013 - National Acad Sciences
Polyadenylation of pre-mRNAs is critical for efficient nuclear export, stability, and translation
of the mature mRNAs, and thus for gene expression. The bulk of pre-mRNAs are processed …

Arabidopsis poly (A) polymerase PAPS 1 limits founder‐cell recruitment to organ primordia and suppresses the salicylic acid‐independent immune response …

G Trost, SL Vi, H Czesnick, P Lange, N Holton… - The Plant …, 2014 - Wiley Online Library
Polyadenylation of pre‐ mRNA s by poly(A) polymerase ( PAPS ) is a critical process in
eukaryotic gene expression. As found in vertebrates, plant genomes encode several isoforms of …

Smad2 isoforms are differentially expressed during mouse brain development and aging

U Ueberham, P Lange, E Ueberham… - International Journal of …, 2009 - Elsevier
Smad2 and Smad3 are central molecules of the TGFβ and activin receptor complex mediated
intracellular signaling pathway. They function as important transcription factors playing …

Implementing the 2005 American Heart Association guidelines, including use of the impedance threshold device, improves hospital discharge rate after in-hospital …

K Thigpen, SP Davis, R Basol, P Lange, SS Jain… - Respiratory …, 2010 - rc.rcjournal.com
OBJECTIVE: To determine the impact of the 2005 American Heart Association cardiopulmonary
resuscitation (CPR) guidelines, including use of an impedance threshold device (ITD), …

What can regenerative medicine offer for infants with laryngotracheal agenesis?

P Lange, JM Fishman, MJ Elliott… - … --Head and Neck …, 2011 - journals.sagepub.com
Background. Laryngotracheal agenesis is a rare congenital disorder but has devastating
consequences. Recent achievements in regenerative medicine have opened up new vistas in …