[HTML][HTML] Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death

E Abraham, PF Laterre, R Garg, H Levy… - … England Journal of …, 2005 - Mass Medical Soc
Background In November 2001, the Food and Drug Administration (FDA) approved drotrecogin
alfa (activated) (DrotAA) for adults who had severe sepsis and a high risk of death. The …

Incidence and prognosis of intraabdominal hypertension in a mixed population of critically ill patients: a multiple-center epidemiological study

…, R Daelemans, L Jacquet, PF Laterre… - Critical care …, 2005 - journals.lww.com
Objective: Intraabdominal hypertension is associated with significant morbidity and mortality
in surgical and trauma patients. The aim of this study was to assess, in a mixed population …

Prevalence of intra-abdominal hypertension in critically ill patients: a multicentre epidemiological study

…, P Cosimini, M Ranieri, L Jacquet, PF Laterre… - Intensive care …, 2004 - Springer
Objective Although intra-abdominal hypertension (IAH) can cause dysfunction of several
organs and raise mortality, little information is available on the incidence and risk factors for IAH …

[HTML][HTML] Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock

FS Taccone, PF Laterre, T Dugernier, H Spapen… - Critical care, 2010 - Springer
Introduction Altered pharmacokinetics (PK) in critically ill patients can result in insufficient
serum β-lactam concentrations when standard dosages are administered. Previous studies on …

SARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule

…, J Dewulf, A Scohy, L Gérard, X Wittebole, PF Laterre… - Kidney international, 2020 - Elsevier
… , Ludovic Gérard 3 8 , Xavier Wittebole 3 8 , Pierre-François Laterre 3 8 , Sara E. Miller 9 ,
Olivier Devuyst 1 3 6 12 , Michel Jadoul 1 7 12 , Johann Morelle 1 3 12 … David Vancraeynest …

[HTML][HTML] Convalescent plasma for Covid-19–induced ARDS in mechanically ventilated patients

…, A Bertrand, AF Donneau, PF Laterre - … England Journal of …, 2023 - Mass Medical Soc
Background Passive immunization with plasma collected from convalescent patients has
been regularly used to treat coronavirus disease 2019 (Covid-19). Minimal data are available …

Lenercept (p55 tumor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: a randomized, double-blind, placebo-controlled, multicenter …

E Abraham, PF Laterre, J Garbino… - Critical care …, 2001 - journals.lww.com
Objective Phase III study to confirm a trend observed in a previous phase II study showing
that a single dose of lenercept, human recombinant p55 tumor necrosis factor receptor-…

A pilot-controlled study of a polymyxin B-immobilized hemoperfusion cartridge in patients with severe sepsis secondary to intra-abdominal infection

JL Vincent, PF Laterre, J Cohen, H Burchardi… - Shock, 2005 - journals.lww.com
Endotoxin is an important pathogenic trigger for sepsis. The polymyxin B-immobilized
endotoxin removal hemoperfusion cartridge, Toraymyxin (hereafter PMX), has been shown to …

[HTML][HTML] Efficacy and safety of recombinant human activated protein C for severe sepsis

GR Bernard, JL Vincent, PF Laterre… - New England journal …, 2001 - Mass Medical Soc
Background Drotrecogin alfa (activated), or recombinant human activated protein C, has
antithrombotic, antiinflammatory, and profibrinolytic properties. In a previous study, drotrecogin …

Liver function abnormalities, clinical profile, and outcome in acute decompensated heart failure

…, D Cai, P Pohjanjousi, PF Laterre… - European heart …, 2013 - academic.oup.com
Aims The aim of this study was to assess the prevalence of abnormal liver function tests (LFTs)
and the associated clinical profile and outcome(s) in acute decompensated heart failure (…