Background The proliferation of inhaler devices has resulted in a confusing number of
choices for clinicians who are selecting a delivery device for aerosol therapy. There are …

The slogan “Coughs and Sneezes Spread Diseases” was coined in the United States during
the last great flu pandemic between 1918 and 1920 to highlight the role of coughs and …

Aerosolised drugs are prescribed for use in a range of inhaler devices and systems. Delivering
drugs by inhalation requires a formulation that can be successfully aerosolised and a …

Ras (p21 ras ) interacts directly with the catalytic subunit of phosphatidylinositol-3-OH kinase
in a GTP-dependent manner through the Ras effector site. In vivo, dominant negative Ras …

Phosphoinositide-3 kinase activity is implicated in diverse cellular responses triggered by
mammalian cell surface receptors and in the regulation of protein sorting in yeast. Receptors …

A collaboration of multidisciplinary experts on the delivery of pharmaceutical aerosols was
facilitated by the European Respiratory Society (ERS) and the International Society for …

Purified bovine brain phosphatidylinositol 3-kinase (PI3-kinase) is composed of 85 kd and
110 kd subunits. The 85 kd subunit (p85α) lacks PI3-kinase activity and acts as an adaptor, …

Affinity-purified bovine brain phosphatidylinositol 3-kinase (PI3-kinase) contains two major
proteins of 85 and 110 kd. Amino acid sequence analysis and cDNA cloning reveals two …

… Indeed, monoclonal antibodies that have epitopes located in the N-terminal SH2 domain
of p85a do not inhibit the binding of pl 10 to the p85 subunits (R.Dhand, unpublished …

Phosphoinositide (PI) 3‐kinases have been characterized as enzymes involved in receptor
signal transduction in mammalian cells and in a complex which mediates protein trafficking …