We have previously reported the development of a transgenic mouse model for prostate
cancer derived from PB-Tag transgenic line 8247, henceforth designated the TRAMP (…

Background Animal models that closely mimic clinical disease can be exploited to hasten the
pace of translational research. To this end, we have defined windows of opportunity in the …

We previously established the autochthonous transgenic adenocarcinoma mouse prostate (TRAMP)
model to facilitate characterization of molecular mechanisms involved in the …

Glutathione (GSH) is a major source of reducing equivalents in mammalian cells. To examine
the role of GSH synthesis in development and cell growth, we generated mice deficient in …

To elucidate the sequence of molecular events intricate with angiogenesis and the initiation
and progression prostate cancer, the temporal and spatial expression patterns of platelet …

Context.—Asthma has been defined as a chronic inflammatory disorder of the airways that is
associated with recruitment of inflammatory cells and the clinical development of wheezing, …

Prostate cancer remains the second leading cause of cancer-related death for men in the
United States. Mutations in tumor suppressor genes including retinoblastoma (Rb), p53, and …

Context.— The diagnosis and grading of acute cellular and antibody-mediated rejection (AMR)
in lung allograft biopsies is important because rejection can lead to acute graft …

Context.— Hypersensitivity pneumonitis (HP) is a lung disease that develops in susceptible
individuals after inhalational exposure to an organic antigen or chemical compound. …

Context.—The classic histopathology of hypersensitivity pneumonitis (HSP) is well known but
variations do occur and at times the diagnosis can be difficult. This is particularly true in the …