User profiles for S. B. Nelson
Sacha NelsonDepartment of Biology, Brandeis University Verified email at brandeis.edu Cited by 35413 |
Homeostatic plasticity in the developing nervous system
GG Turrigiano, SB Nelson - Nature reviews neuroscience, 2004 - nature.com
Activity has an important role in refining synaptic connectivity during development, in part
through 'Hebbian' mechanisms such as long-term potentiation and long-term depression. …
through 'Hebbian' mechanisms such as long-term potentiation and long-term depression. …
Synaptic plasticity: taming the beast
Synaptic plasticity provides the basis for most models of learning, memory and development
in neural circuits. To generate realistic results, synapse-specific Hebbian forms of plasticity, …
in neural circuits. To generate realistic results, synapse-specific Hebbian forms of plasticity, …
[PDF][PDF] Excitatory/inhibitory balance and circuit homeostasis in autism spectrum disorders
SB Nelson, V Valakh - Neuron, 2015 - cell.com
Autism spectrum disorders (ASDs) and related neurological disorders are associated with
mutations in many genes affecting the ratio between neuronal excitation and inhibition. …
mutations in many genes affecting the ratio between neuronal excitation and inhibition. …
Activity-dependent scaling of quantal amplitude in neocortical neurons
Abstract Information is stored in neural circuits through long-lasting changes in synaptic
strengths 1 , 2 . Most studies of information storage have focused on mechanisms such as long-…
strengths 1 , 2 . Most studies of information storage have focused on mechanisms such as long-…
Synaptic depression and cortical gain control
Cortical neurons receive synaptic inputs from thousands of afferents that fire action potentials
at rates ranging from less than 1 hertz to more than 200 hertz. Both the number of afferents …
at rates ranging from less than 1 hertz to more than 200 hertz. Both the number of afferents …
[PDF][PDF] A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex
A key obstacle to understanding neural circuits in the cerebral cortex is that of unraveling
the diversity of GABAergic interneurons. This diversity poses general questions for neural …
the diversity of GABAergic interneurons. This diversity poses general questions for neural …
[HTML][HTML] Rate, timing, and cooperativity jointly determine cortical synaptic plasticity
Cortical long-term plasticity depends on firing rate, spike timing, and cooperativity among
inputs, but how these factors interact during realistic patterns of activity is unknown. Here we …
inputs, but how these factors interact during realistic patterns of activity is unknown. Here we …
An emergent model of orientation selectivity in cat visual cortical simple cells
It is well known that visual cortical neurons respond vigorously to a limited range of stimulus
orientations, while their primary afferent inputs, neurons in the lateral geniculate nucleus (…
orientations, while their primary afferent inputs, neurons in the lateral geniculate nucleus (…
New insights into the classification and nomenclature of cortical GABAergic interneurons
A systematic classification and accepted nomenclature of neuron types is much needed but
is currently lacking. This article describes a possible taxonomical solution for classifying …
is currently lacking. This article describes a possible taxonomical solution for classifying …
Hebb and homeostasis in neuronal plasticity
GG Turrigiano, SB Nelson - Current opinion in neurobiology, 2000 - Elsevier
The positive-feedback nature of Hebbian plasticity can destabilize the properties of neuronal
networks. Recent work has demonstrated that this destabilizing influence is counteracted …
networks. Recent work has demonstrated that this destabilizing influence is counteracted …