Asthma that starts in adulthood differs from childhood-onset asthma in that it is often non-atopic,
more severe and associated with a faster decline in lung function. Understanding of the …

Background Monitoring sputum eosinophils in asthma predicts exacerbations and improves
management of asthma. Thus far, blood eosinophils and FE NO show contradictory results …

Rationale: Chronic obstructive pulmonary disease (COPD) and asthma can exhibit overlapping
clinical features. Exhaled air contains volatile organic compounds (VOCs) that may …

… JC de Groot has received an unrestricted grant from GlaxoSmithKline. SB de Nijs has received
an unrestricted grant from GlaxoSmithKline. PJ Sterk has been supported by one or more …

… ; M Amelink, SB De Nijs, EJM Weersink and … De Nijs and JC de Groot collected the data; R
Lutter was responsible for sputum processing and cell counting; M Amelink, SB de Nijs, JC de …

Several biomarkers have been used to assess sputum eosinophilia in asthma. It has been
suggested that the diagnostic accuracy of these biomarkers might differ between asthma …

Eosinophilic inflammation in chronic obstructive pulmonary disease (COPD) is predictive for
responses to inhaled steroids. We hypothesised that the inflammatory subtype in mild and …

Adult-onset eosinophilic asthma is increasingly recognised as a severe and difficult-to-treat
subtype of asthma. In clinical practice, early recognition of patients with this asthma subtype …

Background Adult-onset asthma is an important but relatively understudied asthma phenotype
and little is known about its natural course and prognosis. The remission rate is believed …

Little is known about the prognosis of adults with new-onset asthma. Cross-sectional studies
suggest that these patients may exhibit accelerated decline in forced expiratory volume in 1 …