Impact of obesity on respiratory function

SW Littleton - Respirology, 2012 - Wiley Online Library
Obesity has long been recognized as having significant effects on respiratory function. The
topic has been studied for at least the last half century, and some clear patterns have …

[HTML][HTML] The effects of obesity on lung volumes and oxygenation

SW Littleton, A Tulaimat - Respiratory medicine, 2017 - Elsevier
Introduction Obesity can cause hypoxemia by decreasing lung volumes to where there is
closure of lung units during normal breathing. Studies describing this phenomenon are difficult …

The Pickwickian syndrome—obesity hypoventilation syndrome

SW Littleton, B Mokhlesi - Clinics in chest medicine, 2009 - chestmed.theclinics.com
The association between obesity and hypersomnolence has long been recognized. Of historical
interest, obesity-hypoventilation syndrome (OHS) was described well before obstructive …

Inhibition of central activation of the diaphragm: a mechanism of weaning failure

F Laghi, H Shaikh, SW Littleton… - Journal of Applied …, 2020 - journals.physiology.org
During a T-tube trial following disconnection of mechanical ventilation, patients failing the trial
do not develop contractile diaphragmatic fatigue despite increases in inspiratory pressure …

Pearls and pitfalls of respiratory testing in a patient with amyotrophic lateral sclerosis and COPD

SW Littleton, F Laghi - Breathe, 2023 - Eur Respiratory Soc
Tweetable abstract Interpretation of pulmonary function testing in patients with amyotrophic
lateral sclerosis must account for coexisting lung diseases, when making patient care …

Is the content of textbooks on the evaluation of a patient in respiratory distress adequate?

A Tulaimat, A Patel, B Shah, SW Littleton - Respiratory care, 2012 - rc.rcjournal.com
BACKGROUND: The ability to rapidly and precisely evaluate patients in respiratory distress
is essential. Due to limited opportunities for formal instruction during training, textbooks are …

Hypercapnia from hyperoxia in COPD: another piece of the puzzle or another puzzle entirely?

SW Littleton - Respiratory Care, 2015 - rc.rcjournal.com
Embarrassment is a powerful teacher. I was barely 3 months into my internship, on night float
at my residency’s Veterans Affairs hospital, when I received a page from a concerned ward …

The history of hypoventilation syndromes

SW Littleton, A Tulaimat - Sleep Medicine Clinics, 2014 - sleep.theclinics.com
The physicians who attended Dionysius, the son of Clearchus, who lived in continual fear of
suffocation from fat, adopted a very curious mode of keeping him awake: they appointed a …

Obesity hypoventilation syndrome

SW Littleton, B Mokhlesi - Obesity and Lung Disease: A Guide to …, 2013 - Springer
Obesity hypoventilation syndrome (OHS) is defined as hypercapnia during wakefulness in
an obese patient, without any other known cause, accompanied with some form of sleep-…

Lack of difference in clinical characteristics using a strict vs. traditional criteria to define REM-related OSA

…, B Patel, J Shah, AS Guralnick, SW Littleton… - C68. OBSTRUCTIVE …, 2010 - atsjournals.org
Background: population, the prevalence of REM OSA based on a traditional definition used
in the literature was 23%. However, the prevalence was reduced to 10% when a more strict …