Optimal outcome in spine surgery is dependent of the coordination of efforts by the surgeon,
anesthesiologist, and neurophysiologist. This is perhaps best illustrated by the rising use of …

BACKGROUND: Choledocholithiasis during pregnancy increases the risk of morbidity and
mortality for both fetus and mother because of cholangitis and pancreatitis. ERCP has been …

OBJECT Major spinal surgery in adult patients is often associated with significant intraoperative
blood loss. Rotational thromboelastometry (ROTEM) is a functional viscoelastometric …

BACKGROUND: Airway inflammation in acute and chronic respiratory diseases is characterized
in part by abnormal pH in airway-lining fluid. The pH of exhaled-breath condensate (…

We have recently discovered a novel class of compounds that have oral general anesthetic
activity, potent anticonvulsant activity, and minimal hemodynamic effects. The 3,3,3-trifluoro-2…

Background Nitric oxide (NO), a recognized cell messenger for activating soluble guanylate
cyclase, is produced by the enzyme NO synthase in a wide variety of tissues, including …

BACKGROUND: Airway acidification plays a role in disorders of the pulmonary tract. We
hypothesized that the inhalation of alkalinized glycine buffer would measurably alkalinize the …

IMPLICATIONS: The nitric oxide-guanylyl cyclase signaling pathway has been proposed to
be involved in sedation, analgesia, and anesthesia. Specific inhibitors of the enzyme nitric …

Background Inhalational anesthetics interact with the nitric oxide-cyclic guanosine monophosphate
(NO-cGMP) pathway in the central nervous system (CNS) and attenuate excitatory …

The metabolism of [2,4- 3 ]5α-cholest-8(14)-en-3β-ol-15-one (I) has been studied in Chinese
hamster ovary (CHO-K1) cells which were maintained in a lipid-deficient medium. The …