Background REGEN-COV is a combination of 2 monoclonal antibodies (casirivimab and
imdevimab) that bind to two different sites on the receptor binding domain of the SARS-CoV-2 …

Background Coronavirus disease 2019 (COVID-19) is associated with diffuse lung damage.
Corticosteroids may modulate immune-mediated lung injury and reducing progression to …

Background The British Thoracic Society (BTS) published the guideline,‘The use of non-invasive
ventilation in acute respiratory failure’, in 2002. 1 This was in response to trials …

Methods A total of 77 patients with confirmed/suspected CRE infection (bacteremia, hospital-acquired/ventilator-associated
bacterial pneumonia, complicated intra-abdominal infection, …

Background Emerging studies indicate that some coronavirus disease 2019 (COVID-19)
patients suffer from persistent symptoms, including breathlessness and chronic fatigue; however…

COVID-19 pathogenesis is associated with an exaggerated immune response. However,
the specific cellular mediators and inflammatory components driving diverse clinical disease …

Infections in critically ill patients are associated with persistently poor clinical outcomes. These
patients have severely altered and variable antibiotic pharmacokinetics and are infected …

With an established role in cystic fibrosis and bronchiectasis, nebulized antibiotics are
increasingly being used to treat respiratory infections in critically ill invasively mechanically …

Understanding the tissue penetration of systemically administered antifungal agents is critical
for a proper appreciation of their antifungal efficacy in animals and humans. Both the time …

Importance In patients who require mechanical ventilation for acute hypoxemic respiratory
failure, further reduction in tidal volumes, compared with conventional low tidal volume …