We describe a laboratory investigation comparing the delivery of chlorofluorocarbon (CFC)-
and hydrofluoroalkane (HFA)-formulated beclomethasone dipropionate (BDP) by metered-…

RESPIRATORY CARE (ISSN 0020-1324, USPS 0489-190) is published monthly by
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… JP Mitchell, MW Nagel, CC Doyle, KJWiersema Trudell Medical International, 725 Third St.,
London, Ontario, Canada, N5V 5G4 VA Migounov & 3M Pharmaceuticals, London, Ontario, …

Background 5% Imiquimod cream is a topical immune response modifier that has been
used off-label to treat malignant melanocytic proliferations such as lentigo maligna. To our …

Variability in excipient powders used in aerosol formulations create a significant formulation
and manufacturing challenge. Batch-to-batch variability of excipients, even from a single …

Pressurized metered-dose inhalers (pMDIs) are commonly employed for administering
bronchodilator aerosols to mechanically ventilated patients. Although it is feasible to employ dry …

… This work was supported by the VA Research Service. The author has received research
funding from Omron Inc. (Bannockburn, IL), Trudell Medical International (London, ON) and con…

… Le dépôt dans les voies aériennes et les alvéoles va donc dépendre du MMAD. Celui-ci est
défini pour chaque système de nébulisation. Pour obtenir un dépôt pulmonaire profond, c’est…

Experiments were conducted to illustrate some of the challenges associated with measuring
dynamic MDI aerosols. Experimental HFA-134a solution MDIs containing 8 or 20% ethanol …

Background Combining a positive expiratory pressure (PEP) device with inhalation of albuterol
via metered dose inhaler (MDI) may improve drug delivery to the lung, but may also affect …