Background Chronic obstructive pulmonary disease (COPD) is characterized by an incompletely
reversible limitation in airflow. A physiological variable — the forced expiratory volume …

Rationale: Patients with chronic obstructive pulmonary disease (COPD) are afflicted by
comorbidities. Few studies have prospectively evaluated COPD comorbidities and mortality risk. …

Background Chronic obstructive pulmonary disease (COPD) is thought to result from an
accelerated decline in forced expiratory volume in 1 second (FEV 1 ) over time. Yet it is possible …

Static lung hyperinflation has important clinical consequences in patients with chronic obstructive
pulmonary disease. We analyzed the power of lung hyperinflation as measured by the …

Background: Patients with chronic obstructive pulmonary disease (COPD) have raised serum
levels of C reactive protein (CRP). This may be related directly to COPD and its associated …

Rationale The distance walked in the 6-min walk test (6MWT) predicts mortality in patients
with severe COPD. Little is known about its prognostic value in patients with a wider range of …

Rationale: Outcomes other than spirometry are required to assess nonbronchodilator therapies
for chronic obstructive pulmonary disease. Estimates of the minimal clinically important …

Study objectives Several validated instruments are used to measure outcomes, such as
exercise performance, dyspnea, and health-related quality of life after pulmonary rehabilitation (…

In patients with COPD, the maximal oxygen uptake ( V o 2 ) measured at peak exercise and
the 6-min walk distance (6MWD) have been associated with survival; however, no study has …

Importance Meta-analyses have suggested that initiating pulmonary rehabilitation after an
exacerbation of chronic obstructive pulmonary disease (COPD) was associated with improved …