Spontaneous respiratory effort during mechanical ventilation has long been recognized to
improve oxygenation, and because oxygenation is a key management target, such effort may …

Objective: We investigated whether potentially injurious transpulmonary pressure could be
generated by strong spontaneous breathing and exacerbate lung injury even when plateau …

Objectives: The benefits of spontaneous breathing over muscle paralysis have been proven
mainly in mild lung injury; no one has yet evaluated the effects of spontaneous breathing in …

Rationale: In acute respiratory distress syndrome (ARDS), atelectatic solid-like lung tissue
impairs transmission of negative swings in pleural pressure (Ppl) that result from …

Background Phosphodiesterase type 5 (PDE5) hydrolyzes cyclic guanosine monophosphate
in the lung, thereby modulating nitric oxide (NO)/cyclic guanosine monophosphate-…

Rationale: Spontaneous breathing during mechanical ventilation increases transpulmonary
pressure and Vt, and worsens lung injury. Intuitively, controlling Vt and transpulmonary …

… b,c ; Brochard, Laurent d ; Fujino, Yuji a … Yoshida T, Fujino Y, Amato MB, Kavanagh BP.
Fifty years of research in ARDS: spontaneous breathing during mechanical ventilation: risks …

Background A lung-protecting strategy is essential when ventilating acute lung injury/acute
respiratory distress syndrome patients. Current emphasis is on limiting inspiratory pressure …

Objectives The prevention of delirium is an important issue in the field of perioperative
nursing. The objective of this study was to verify the usefulness of acute-stage bright light …

We update and summarize the role of spontaneous breathing during mechanical ventilation
in ARDS, which can be beneficial or deleterious, depending on the strength of spontaneous …