[HTML][HTML] Verification, analytical validation, and clinical validation (V3): the foundation of determining fit-for-purpose for Biometric Monitoring Technologies (BioMeTs)

…, JG Godino, N Gujar, E Izmailova, C Manta… - npj digital …, 2020 - nature.com
Digital medicine is an interdisciplinary field, drawing together stakeholders with expertize in
engineering, manufacturing, clinical science, data science, biostatistics, regulatory science, …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

…, L Maggi, MK Maini, F Mair, C Manta… - European journal of …, 2021 - Wiley Online Library
The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

Digital measures that matter to patients: a framework to guide the selection and development of digital measures of health

C Manta, B Patrick-Lake, JC Goldsack - Digital Biomarkers, 2020 - karger.com
Background: With the rise of connected sensor technologies, there are seemingly endless
possibilities for new ways to measure health. These technologies offer researchers and …

[HTML][HTML] CX3CR1+ macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium

C Manta, E Heupel, K Radulovic, V Rossini, N Garbi… - Mucosal …, 2013 - Elsevier
… Using a murine model of innate-mediated protection against C. rodentium, we show that
clearance of C. rodentium is delayed in the absence of CX 3 CR1. CX 3 CR1-GFP animals on a …

Targeting of scavenger receptors stabilin-1 and stabilin-2 ameliorates atherosclerosis by a plasma proteome switch mediating monocyte/macrophage suppression

CP Manta, T Leibing, M Friedrich, H Nolte, M Adrian… - Circulation, 2022 - Am Heart Assoc
… B and C, Volcano plots showing log2 fold changes (FC) of detected plasma proteins on
the x axis and the –log10 P value (2-sided t test) on the y axis. B, ApoE-KO versus ApoE-Stab1-…

[HTML][HTML] Modernizing and designing evaluation frameworks for connected sensor technologies in medicine

A Coravos, M Doerr, J Goldsack, C Manta… - NPJ digital …, 2020 - nature.com
This manuscript is focused on the use of connected sensor technologies, including wearables
and other biosensors, for a wide range of health services, such as collecting digital …

CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential

K Radulovic, C Manta, V Rossini… - The Journal of …, 2012 - journals.aai.org
… The activation Ag CD69 (encoded in the NK C-type lectin gene cluster) is a type II
transmembrane protein of the C-type lectin family (11–13). In contrast to other members of the NK C-…

An evaluation of biometric monitoring technologies for vital signs in the era of COVID‐19

C Manta, SS Jain, A Coravos… - Clinical and …, 2020 - Wiley Online Library
… For example, readings from the armpit and forehead are often 0.5F (0.3C) to 1F (0.6C)
lower than oral temperature. Comparatively, product manuals from nine BioMeTs spanning …

[HTML][HTML] The early activation marker CD69 regulates the expression of chemokines and CD4 T cell accumulation in intestine

K Radulovic, V Rossini, C Manta, K Holzmann… - PloS one, 2013 - journals.plos.org
Migration of naïve and activated lymphocytes is regulated by the expression of various
molecules such as chemokine receptors and ligands. CD69, the early activation marker of C-type …

[HTML][HTML] General hospital staff worries, perceived sufficiency of information and associated psychological distress during the A/H1N1 influenza pandemic

P Goulia, C Mantas, D Dimitroula, D Mantis… - BMC infectious …, 2010 - Springer
… Items were grouped in seven domains: (a) HCWs' concerns, worries and degree of worry
about the A/H1N1 influenza pandemic, (b) perceived sufficiency of information, (c) confidence …