Objective: To provide a general descriptive account of the end-organ effects of dexmedetomidine
and to provide an evidence-based review of the literature regarding its use in infants …

Tolerance, withdrawal, and physical dependency after long-te... : Critical Care Medicine
Tolerance, withdrawal, and physical dependency after long-term sedation and analgesia of …

Given the continued increase in the complexity of invasive and noninvasive procedures,
healthcare practitioners are faced with a larger number of patients requiring procedural sedation…

Control of pain and stress for children is a vital component of emergency medical care.
Timely administration of analgesia affects the entire emergency medical experience and can …

Background: We sought to compare the efficacy of midazolam versus dexmedetomidine for
sedation during mechanical ventilation in infants and children. Methods: We performed a …

We present preliminary clinical experience with the use of dexmedetomidine, an α 2 adrenergic
agonist, in children. Dexmedetomidine was administered in three clinical scenarios: (i) to …

… reviewed and revised the manuscript; Drs Kim and Uffman contributed to the idea conception
and interpretation of the data and critically reviewed and revised the manuscript; Dr Tobias …

… More recently, McVey and Tobias ( 19 ) described their experience using these agents
during lumbar puncture for spinal anesthesia in 12 pediatric patients. The dosing regimen was …

Background : Flexible fiberoptic bronchoscopy is an important diagnostic tool for pediatric
pulmonologists. Because of its favorable respiratory profile, ketamine has become a popular …

Objective: To determine the effect of manual ventilation during intrahospital transport on end-tidal
carbon dioxide concentrations in children. Design: Prospective study in children who …