Research and practice in critical care medicine have long been defined by syndromes,
which, despite being clinically recognizable entities, are, in fact, loose amalgams of …

Acute respiratory distress syndrome (ARDS) is an acute respiratory illness characterised by
bilateral chest radiographical opacities with severe hypoxaemia due to non-cardiogenic …

Acute respiratory distress syndrome (ARDS) is a heterogeneous clinical syndrome. Understanding
of the complex pathways involved in lung injury pathogenesis, resolution, and repair …

INTRODUCTION Many patients with coronavirus disease 2019 (COVID-19), caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, present with severe …

Patients with cancer have high mortality from coronavirus disease 2019 (COVID-19), and
the immune parameters that dictate clinical outcomes remain unknown. In a cohort of 100 …

Although critical illness has been associated with SARS-CoV-2–induced hyperinflammation,
the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively …

COVID-19 is associated with a wide range of clinical manifestations, including autoimmune
features and autoantibody production. Here we develop three protein arrays to measure IgG …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread within
the human population. Although SARS-CoV-2 is a novel coronavirus, most humans had been …

Rationale: Despite advances in clinical management, there are currently no reliable
diagnostic and therapeutic targets for acute respiratory distress syndrome (ARDS). The …

Background Mitochondrial DNA (mtDNA) is a critical activator of inflammation and the innate
immune system. However, mtDNA level has not been tested for its role as a biomarker in …