BACKGROUND Heterogeneity within a given cancer arises from diverse cell types recruited
to the tumor and from genetic and/or epigenetic differences amongst the cancer cells …

High-flow nasal cannula (HFNC) oxygen therapy is a recent technique delivering a high
flow of heated and humidified gas. HFNC is simpler to use and apply than noninvasive …

Genetic screens help infer gene function in mammalian cells, but it has remained difficult to
assay complex phenotypes—such as transcriptional profiles—at scale. Here, we develop …

… Assuming that there were N m marker genes for cell type m, we considered these N m genes
combined as a ‘meta-gene’ with counts \(f_i^m = \mathop {\sum}\limits_j^{N_m} {x_{i,j}}\) in …

… Quantification of differential ZEB1 expression in basal cell lines (n = 4). … The functional
state of chromatin has been defined largely by patterns of covalent modifications to the N-terminal …

By dividing asymmetrically, stem cells can generate two daughter cells with distinct fates.
However, evidence is limited in mammalian systems for the selective apportioning of …

Tumor evolution from a single cell into a malignant, heterogeneous tissue remains poorly
understood. Here, we profile single-cell transcriptomes of genetically engineered mouse lung …

The expression of co-inhibitory receptors, such as CTLA-4 and PD-1, on effector T cells is a
key mechanism for ensuring immune homeostasis. Dysregulated expression of co-inhibitory …

Reversing the dysfunctional T cell state that arises in cancer and chronic viral infections is
the focus of therapeutic interventions; however, current therapies are effective in only some …

The diversity of mesenchymal cell types in the lung that influence epithelial homeostasis
and regeneration is poorly defined. We used genetic lineage tracing, single-cell RNA …