Infections in critically ill patients are associated with persistently poor clinical outcomes. These
patients have severely altered and variable antibiotic pharmacokinetics and are infected …

Understanding the tissue penetration of systemically administered antifungal agents is critical
for a proper appreciation of their antifungal efficacy in animals and humans. Both the time …

Background Coronavirus disease 2019 (COVID-19) is associated with diffuse lung damage.
Corticosteroids may modulate immune-mediated lung injury and reducing progression to …

Critically ill patients with severe infections are at high risk of suboptimal antimicrobial dosing.
The pharmacokinetics (PK) and pharmacodynamics (PD) of antimicrobials in these patients …

Background REGEN-COV is a combination of 2 monoclonal antibodies (casirivimab and
imdevimab) that bind to two different sites on the receptor binding domain of the SARS-CoV-2 …

Importance In patients who require mechanical ventilation for acute hypoxemic respiratory
failure, further reduction in tidal volumes, compared with conventional low tidal volume …

… Tim Felton received consultancy fees from Gilead, GSK and Pfizer. Elizabeth L. Alexander
was an employee of The Medicines Company during the study and retains stock on the …

Background The British Thoracic Society (BTS) published the guideline,‘The use of non-invasive
ventilation in acute respiratory failure’, in 2002. 1 This was in response to trials …

… 2, we next investigated alterations to specific T and B cell populations by flow cytometrically
… Focusing on T cells, the phenotype and function of circulating T cells remain an issue with …

The choice of using one of many possible neurotransmitter systems is a critical step in defining
the identity of an individual neuron type. We show here that the key defining feature of …