Abstract
Prospective clinical research is given the greatest weight in evidence-based clinical practice recommendations, and therefore has the greatest potential to change care and help the largest number of patients. This article briefly describes the history of government regulation of prospective clinical research, how a prospective clinical research project is developed, and how the researcher seeks project approval from the institutional review board. We also evaluate 2 published studies with regard to ethical and regulatory matters that influenced the studies.
- research
- respiratory care
- clinical trials
- institutional review board
- informed consent
- research methodology
Footnotes
- Correspondence: Charles G Durbin Jr MD FAARC, Department of Anesthesiology, University of Virginia Health Science Center, PO Box 800710, Charlottesville VA 22908-0170. E-mail: cgd8v{at}viriginia.edu.
- Copyright © 2004 by Daedalus Enterprises Inc.