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Research ArticleOriginal Contributions

Medical Nebulizer Performance: Effects of Cascade Impactor Temperature

Yue Zhou, Amitkumar Ahuja, Clinton M Irvin, Dean A Kracko, Jacob D McDonald and Yung-Sung Cheng
Respiratory Care August 2005, 50 (8) 1077-1082;
Yue Zhou
Lovelace Respiratory Research Institute, Albuquerque, New Mexico.
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  • For correspondence: [email protected]
Amitkumar Ahuja
City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, California.
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Clinton M Irvin
Lovelace Respiratory Research Institute, Albuquerque, New Mexico
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Dean A Kracko
Lovelace Respiratory Research Institute, Albuquerque, New Mexico
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Jacob D McDonald
Lovelace Respiratory Research Institute, Albuquerque, New Mexico
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Yung-Sung Cheng
Lovelace Respiratory Research Institute, Albuquerque, New Mexico
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Abstract

BACKGROUND: During operation of a jet nebulizer, the temperature of the nebulizer outlet could decrease by more than 10°C, depending on the nebulizer type and operating conditions, such as driving flow rate and fill volume. The droplet size distribution generated from the nebulizer can be measured by a cascade impactor. However, when the cascade impactor is operated at ambient room temperature, the droplets could evaporate because of the temperature difference between the nebulizer outlet and the body of the impactor.

METHODS: An 8-stage cascade impactor was used to measure the particle size distribution from 4 different types of jet nebulizer (LC Plus, Side-Stream, VixOne, and Micromist) in 2 temperature conditions: ambient (22°C) and low (10°C). Two different formulations, albuterol (aqueous solution) and budesonide (suspension), were used.

RESULTS: There was a significantly larger (p < 0.05) mass median aerodynamic diameter and smaller respirable fraction for each nebulizer with the impactor at low temperature than with the impactor at ambient temperature. The mass median aerodynamic diameter of the nebulizers with the impactor operating at low temperature appeared 15–130% larger than with the impactor operating at ambient temperature, for both formulations. The respirable fraction also changed from 10% when the impactor was operated at low temperature to 65% when the impactor was operated at ambient temperature.

CONCLUSION: The results provide important information for the use of a cascade impactor to measure the particle-size distribution of nebulizer aerosols.

  • nebulizer
  • aerosol
  • cascade impactor

Footnotes

  • Correspondence: Yue Zhou PhD, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque NM 87108. E-mail: yzhou{at}lrri.org.
  • Copyright © 2005 by Daedalus Enterprises Inc.
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Respiratory Care: 50 (8)
Respiratory Care
Vol. 50, Issue 8
1 Aug 2005
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Medical Nebulizer Performance: Effects of Cascade Impactor Temperature
Yue Zhou, Amitkumar Ahuja, Clinton M Irvin, Dean A Kracko, Jacob D McDonald, Yung-Sung Cheng
Respiratory Care Aug 2005, 50 (8) 1077-1082;

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Medical Nebulizer Performance: Effects of Cascade Impactor Temperature
Yue Zhou, Amitkumar Ahuja, Clinton M Irvin, Dean A Kracko, Jacob D McDonald, Yung-Sung Cheng
Respiratory Care Aug 2005, 50 (8) 1077-1082;
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Keywords

  • nebulizer
  • aerosol
  • cascade impactor

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