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Research ArticleConference Proceedings

Principles of Metered-Dose Inhaler Design

Stephen P Newman
Respiratory Care September 2005, 50 (9) 1177-1190;
Stephen P Newman
Pharmaceutical Profiles Ltd, Nottingham, United Kingdom.
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Abstract

The pressurized metered-dose inhaler (pMDI) was introduced to deliver asthma medications in a convenient and reliable multi-dose presentation. The key components of the pMDI device (propellants, formulation, metering valve, and actuator) all play roles in the formation of the spray, and in determining drug delivery to the lungs. Hence the opportunity exists to design a pMDI product by adjusting the formulation, metering-valve size, and actuator nozzle diameter in order to obtain the required spray characteristics and fine-particle dose. Breath-actuated pMDIs, breath-coordinated pMDIs, spray-velocity modifiers, and spacer devices may be useful for patients who cannot use a conventional press-and-breathe pMDI correctly. Modern pMDI devices, which contain nonozone-depleting propellants, should allow inhalation therapy via pMDI to extend well into the 21st century for a variety of treatment indications.

  • metered-dose inhaler
  • MDI
  • asthma
  • chronic obstructive pulmonary disease
  • spacer
  • aerosol
  • drug delivery

Footnotes

  • Correspondence: Stephen P Newman PhD. E-mail: steve.newman{at}physics.org.
  • Copyright © 2005 by Daedalus Enterprises Inc.
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Respiratory Care: 50 (9)
Respiratory Care
Vol. 50, Issue 9
1 Sep 2005
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Principles of Metered-Dose Inhaler Design
Stephen P Newman
Respiratory Care Sep 2005, 50 (9) 1177-1190;

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Principles of Metered-Dose Inhaler Design
Stephen P Newman
Respiratory Care Sep 2005, 50 (9) 1177-1190;
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Keywords

  • metered-dose inhaler
  • MDI
  • asthma
  • chronic obstructive pulmonary disease
  • spacer
  • aerosol
  • drug delivery

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