Skip to main content
 

Main menu

  • Home
  • Content
    • Current Issue
    • Editor's Commentary
    • Coming Next Month
    • Archives
    • Most-Read Papers of 2021
  • Authors
    • Author Guidelines
    • Submit a Manuscript
  • Reviewers
    • Reviewer Information
    • Create Reviewer Account
    • Reviewer Guidelines: Original Research
    • Reviewer Guidelines: Reviews
    • Appreciation of Reviewers
  • CRCE
    • Through the Journal
    • JournalCasts
    • AARC University
    • PowerPoint Template
  • Open Forum
    • 2022 Call for Abstracts
    • 2021 Abstracts
    • Previous Open Forums
  • Podcast
    • English
    • Español
    • Portugûes
    • 国语
  • Videos
    • Video Abstracts
    • Author Interviews
    • Highlighted Articles
    • The Journal

User menu

  • Subscribe
  • My alerts
  • Log in

Search

  • Advanced search
American Association for Respiratory Care
  • Subscribe
  • My alerts
  • Log in
American Association for Respiratory Care

Advanced Search

  • Home
  • Content
    • Current Issue
    • Editor's Commentary
    • Coming Next Month
    • Archives
    • Most-Read Papers of 2021
  • Authors
    • Author Guidelines
    • Submit a Manuscript
  • Reviewers
    • Reviewer Information
    • Create Reviewer Account
    • Reviewer Guidelines: Original Research
    • Reviewer Guidelines: Reviews
    • Appreciation of Reviewers
  • CRCE
    • Through the Journal
    • JournalCasts
    • AARC University
    • PowerPoint Template
  • Open Forum
    • 2022 Call for Abstracts
    • 2021 Abstracts
    • Previous Open Forums
  • Podcast
    • English
    • Español
    • Portugûes
    • 国语
  • Videos
    • Video Abstracts
    • Author Interviews
    • Highlighted Articles
    • The Journal
  • Twitter
  • Facebook
  • YouTube
Research ArticleConference Proceedings

Critical Illness and Mechanical Ventilation: Effects on the Diaphragm

Amal Jubran
Respiratory Care September 2006, 51 (9) 1054-1064;
Amal Jubran
Division of Pulmonary and Critical Care Medicine, Edward Hines Jr Veterans Affairs Hospital and Loyola University of Chicago Stritch School of Medicine, Hines, Illinois.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected]
  • Article
  • References
  • Info & Metrics
  • PDF
Loading

Abstract

Although life-saving, mechanical ventilation is associated with numerous complications. These include pneumonia, cardiovascular compromise, barotrauma, and ventilator-induced lung injury. Recent data from animal studies suggest that controlled mechanical ventilation can cause dysfunction of the diaphragm, decreasing its force-generating capacity—a condition referred to as ventilator-induced diaphragmatic dysfunction (VIDD). The decrease in diaphragmatic contractility is time-dependent and worsens as mechanical ventilation is prolonged. Evidence supporting the occurrence of comparable diaphragmatic dysfunction in critically ill patients is scarce, although most patients receiving mechanical ventilation display profound diaphragmatic weakness. Atrophy, fibers remodeling, oxidative stress, and structural injury have been implicated as potential mechanisms of VIDD. The decrease in diaphragmatic force that occurs during controlled mechanical ventilation is attenuated during assisted modes of ventilation. Whether the decrease in diaphragmatic contractility observed during controlled ventilation contributes to failure to wean from the ventilator is difficult to ascertain. Weaning-failure patients have reasons other than VIDD for respiratory-muscle weakness. Until we have further data, it seems prudent to avoid the use of controlled mechanical ventilation in patients with acute respiratory failure.

  • mechanical ventilation
  • complications
  • pneumonia
  • cardiovascular
  • barotrauma
  • ventilator
  • lung injury
  • diaphragm
  • weakness
  • atrophy
  • fiber remodeling
  • oxidative stress
  • acute respiratory failure

Footnotes

  • Correspondence: Amal Jubran MD, Division of Pulmonary and Critical Care Medicine, Edward Hines Jr Veterans Affairs Hospital, 5th Avenue and Roosevelt Road, Hines, Illinois 60141. E-mail: ajubran{at}lumc.edu.
  • Amal Jubran MD presented a version of this paper at the 37th RESPIRATORY CARE Journal Conference, “Neuromuscular Disease in Respiratory and Critical Care Medicine,” held March 17-19, 2006, in Ixtapa, Mexico.

  • Copyright © 2006 by Daedalus Enterprises Inc.
PreviousNext
Back to top

In this issue

Respiratory Care: 51 (9)
Respiratory Care
Vol. 51, Issue 9
1 Sep 2006
  • Table of Contents
  • Table of Contents (PDF)
  • Cover (PDF)
  • Index by author

 

Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on American Association for Respiratory Care.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Critical Illness and Mechanical Ventilation: Effects on the Diaphragm
(Your Name) has sent you a message from American Association for Respiratory Care
(Your Name) thought you would like to see the American Association for Respiratory Care web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Critical Illness and Mechanical Ventilation: Effects on the Diaphragm
Amal Jubran
Respiratory Care Sep 2006, 51 (9) 1054-1064;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Critical Illness and Mechanical Ventilation: Effects on the Diaphragm
Amal Jubran
Respiratory Care Sep 2006, 51 (9) 1054-1064;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • References
  • PDF

Related Articles

Cited By...

Keywords

  • mechanical ventilation
  • complications
  • pneumonia
  • cardiovascular
  • barotrauma
  • ventilator
  • lung injury
  • diaphragm
  • weakness
  • atrophy
  • fiber remodeling
  • oxidative stress
  • acute respiratory failure

Info For

  • Subscribers
  • Institutions
  • Advertisers

About Us

  • About the Journal
  • Editorial Board
  • Reprints/Permissions

AARC

  • Membership
  • Meetings
  • Clinical Practice Guidelines

More

  • Contact Us
  • RSS
American Association for Respiratory Care

Print ISSN: 0020-1324        Online ISSN: 1943-3654

© Daedalus Enterprises, Inc.

Powered by HighWire