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Research ArticleSymposium Papers

Inhaled Corticosteroids in Obstructive Airway Disease

Ghee-Chee Phua and Neil R Macintyre
Respiratory Care July 2007, 52 (7) 852-858;
Ghee-Chee Phua
Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Duke University, Durham, North Carolina, and with the Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore
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Neil R Macintyre
Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Duke University, Durham, North Carolina
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Abstract

Inhaled corticosteroids play an important role in the management of obstructive airway disease, by suppressing airway inflammation that is central to the pathophysiology of these conditions. In asthma there is strong clinical evidence supporting the use of inhaled corticosteroids in mild, moderate, and severe persistent asthma to improve lung function, reduce exacerbations, and prevent death. In chronic obstructive pulmonary disease, inhaled corticosteroids improve symptoms, reduce frequency of exacerbations and hospitalizations, and should be considered in patients with moderate-to-severe airflow limitation who have persistent symptoms despite optimal bronchodilator therapy. Though the adverse effects of corticosteroids are less when given via inhalation than when given systemically, nevertheless, the adverse effects are important and need to be considered. Newer inhaled corticosteroids with better pharmacologic properties are being developed and will probably be available in the near future.

  • chronic obstructive pulmonary disease
  • asthma
  • corticosteroids
  • aerosols
  • administration
  • inhalation
  • metered-dose inhaler

Footnotes

  • Correspondence: Neil R MacIntyre MD FAARC, Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Duke University Medical Center, Durham NC 27710. E-mail: neil.macintyre{at}duke.edu.
  • Dr MacIntyre presented a version of this paper at the 22nd Annual New Horizons Symposium at the 52nd International Respiratory Congress of the American Association for Respiratory Care, held December 11–14, 2006, in Las Vegas, Nevada.

  • Dr MacIntyre serves as a consultant to Trudell Medical, a manufacturer of aerosol-related devices. Dr Phua reports no conflicts of interest related to the content of this paper.

  • Copyright © 2007 by Daedalus Enterprises Inc.
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Respiratory Care: 52 (7)
Respiratory Care
Vol. 52, Issue 7
1 Jul 2007
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Inhaled Corticosteroids in Obstructive Airway Disease
Ghee-Chee Phua, Neil R Macintyre
Respiratory Care Jul 2007, 52 (7) 852-858;

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Inhaled Corticosteroids in Obstructive Airway Disease
Ghee-Chee Phua, Neil R Macintyre
Respiratory Care Jul 2007, 52 (7) 852-858;
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Keywords

  • chronic obstructive pulmonary disease
  • asthma
  • corticosteroids
  • aerosols
  • administration
  • inhalation
  • metered-dose inhaler

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