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Review ArticleReview Articles

The Obesity Hypoventilation Syndrome

Mark Anthony Powers
Respiratory Care December 2008, 53 (12) 1723-1730;
Mark Anthony Powers
Duke Asthma, Allergy, and Airway Center, Duke University Medical Center, Durham, North Carolina.
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Abstract

We only need to look around us to see that we are in an epidemic of obesity and obesity-related medical problems. The obesity hypoventilation syndrome is a disorder in which an obese person with normal lungs chronically hypoventilates. Obesity impairs ventilatory mechanics, increases the work of breathing and carbon dioxide production, results in respiratory muscle dysfunction, and reduces ventilatory response to hypercapnia. Sleep-disordered breathing is present in most patients with the obesity hypoventilation syndrome. When noninvasive ventilation can be successfully introduced, hypoventilation can usually be corrected. Weight loss is the desirable long-term treatment for the obesity hypoventilation syndrome. This paper concisely overviews the physiologic factors that lead to the obesity hypoventilation syndrome and discusses therapies for it.

  • obesity hypoventilation syndrome
  • OHS
  • Pickwickian syndrome
  • simple obesity
  • ventilatory drive
  • compliance
  • airways resistance
  • work of breathing
  • respiratory muscle endurance
  • sleep apnea syndrome
  • noninvasive positive-pressure ventilation

Footnotes

  • Correspondence: Mark Anthony Powers MD, Duke Asthma, Allergy, and Airway Center, Duke University Medical Center, 4309 Medical Park Drive, Suite 100, Durham NC 27704. Email: mark.powers{at}duke.edu.
  • The author reports no conflicts of interest related to the content of this paper..

  • Copyright © 2008 by Daedalus Enterprises Inc.
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Respiratory Care: 53 (12)
Respiratory Care
Vol. 53, Issue 12
1 Dec 2008
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The Obesity Hypoventilation Syndrome
Mark Anthony Powers
Respiratory Care Dec 2008, 53 (12) 1723-1730;

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Mark Anthony Powers
Respiratory Care Dec 2008, 53 (12) 1723-1730;
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Keywords

  • obesity hypoventilation syndrome
  • OHS
  • Pickwickian syndrome
  • simple obesity
  • ventilatory drive
  • compliance
  • airways resistance
  • Work of Breathing
  • respiratory muscle endurance
  • sleep apnea syndrome
  • noninvasive positive-pressure ventilation

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Print ISSN: 0020-1324        Online ISSN: 1943-3654

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