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Research ArticleOriginal Research

Lung Diffusing Capacity in Adult Bronchiectasis: A Longitudinal Study

Paul T King, Stephen R Holdsworth, Nicholas J Freezer, Elmer Villanueva, Michael W Farmer, Paul Guy and Peter W Holmes
Respiratory Care December 2010, 55 (12) 1686-1692;
Paul T King
Department of Respiratory and Sleep Medicine
Department of Medicine, Monash Medical Centre
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  • For correspondence: [email protected]
Stephen R Holdsworth
Department of Medicine, Monash Medical Centre
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Nicholas J Freezer
Department of Respiratory and Sleep Medicine
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Elmer Villanueva
Gippsland Medical School, Monash University, Melbourne, Victoria, Australia.
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Michael W Farmer
Department of Respiratory and Sleep Medicine
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Paul Guy
Department of Respiratory and Sleep Medicine
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Peter W Holmes
Department of Respiratory and Sleep Medicine
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Abstract

BACKGROUND: Recent studies described a progressive decline in lung volumes in adult bronchiectasis. Interstitial lung disease is also a feature of bronchiectasis, but whether this is associated with a decline in lung diffusing capacity (measured as the diffusing capacity of the lung for carbon monoxide [DLCO]) is not well known.

OBJECTIVE: To assess longitudinal decline in diffusing capacity of the lung for carbon monoxide (DLCO) in adult bronchiectasis.

METHODS: Sixty-one subjects had a detailed baseline clinical and laboratory assessment, then were followed regularly with clinical and lung-function assessment for a median 7 years.

RESULTS: Baseline spirometry demonstrated mild obstructive lung disease, with a mean FEV1 of 72% of predicted, mean forced vital capacity 87% of predicted, and normal DLCO (mean DLCO 88% of predicted, and mean DLCO adjusted for alveolar volume [DLCO/VA] 100% of predicted). There was an accelerated decline in DLCO and DLCO/VA over the 7-year period. The median DLCO decline was 2.9% of predicted per year (95% CI 2.3–4.1% of predicted per year). The median DLCO/VA decline was 2.4% of predicted per year (95% CI 2.1–4.0% of predicted per year). There was a significant relationship between DLCO decline and age and decline in FEV1.

CONCLUSIONS: In our cohort of patients with bronchiectasis there was a progressive DLCO decline.

  • bronchiectasis
  • diffusing capacity of the lung for carbon monoxide
  • DLCO
  • interstitial lung disease
  • FEV1
  • forced vital capacity
  • pulmonary function test

Footnotes

  • Correspondence: Paul T King, Department of Respiratory and Sleep Medicine, Monash Medical Centre, 246 Clayton Road, Clayton, Melbourne, Australia, 3168. E-mail: paul.king{at}med.monash.edu.au.
  • This research was partly supported by a grant (to Dr King) from the National Health and Medical Research Council of Australia.

  • The authors have disclosed no conflicts of interest.

  • Copyright © 2010 by Daedalus Enterprises Inc.
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Respiratory Care: 55 (12)
Respiratory Care
Vol. 55, Issue 12
1 Dec 2010
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Lung Diffusing Capacity in Adult Bronchiectasis: A Longitudinal Study
Paul T King, Stephen R Holdsworth, Nicholas J Freezer, Elmer Villanueva, Michael W Farmer, Paul Guy, Peter W Holmes
Respiratory Care Dec 2010, 55 (12) 1686-1692;

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Lung Diffusing Capacity in Adult Bronchiectasis: A Longitudinal Study
Paul T King, Stephen R Holdsworth, Nicholas J Freezer, Elmer Villanueva, Michael W Farmer, Paul Guy, Peter W Holmes
Respiratory Care Dec 2010, 55 (12) 1686-1692;
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Keywords

  • bronchiectasis
  • diffusing capacity of the lung for carbon monoxide
  • DLCO
  • interstitial lung disease
  • FEV1
  • forced vital capacity
  • pulmonary function test

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