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Research ArticleOriginal Research

Effective Inspired Oxygen Concentration Measured Via Transtracheal and Oral Gas Analysis

Gerald H Markovitz, James Colthurst, Thomas W Storer and Christopher B Cooper
Respiratory Care April 2010, 55 (4) 453-459;
Gerald H Markovitz
Exercise Physiology Research Laboratory, David Geffen School of Medicine, University of California, Los Angeles, California.
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James Colthurst
Eumedic, Hungerford, Berkshire, United Kingdom.
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Thomas W Storer
Exercise Science Laboratory, El Camino College, Torrance, California
Exercise Physiology Research Laboratory at UCLA.
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Christopher B Cooper
Exercise Physiology Research Laboratory, David Geffen School of Medicine, University of California, Los Angeles, California.
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    Fig. 1.

    Raw data from gas sampling at the mouthpiece during quiet breathing (nasal cannula). Left column (A): fractional concentration of carbon dioxide plotted against fractional concentration of oxygen without supplemental oxygen (room air) and with supplemental oxygen (47%) at 4, 6, and 8 L/min. Right column (B): Examples of FO2 and FCO2 in real time from a patient breathing room air, and while breathing supplemental oxygen (47%) at 4, 6, and 8 L/min.

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    Fig. 2.

    The O2−CO2 diagram of Rahn and Fenn.6 To find the effective fraction of inspired oxygen (effective FIO2) we extrapolate along the gas line to the intersection on the X axis and convert PIO2 (partial pressure of inspired oxygen) to FIO2. I = inspired point. E′ = end-expired point. ̄E = mixed expired point. A = alveolar point. a = arterial point. v̄ = mixed venous point.

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    Fig. 3.

    Effective fraction of inspired oxygen (effective FIO2) measured at the mouthpiece versus in the trachea. There was excellent correlation, based on 59 paired measurements (r = 0.960, P < .001).

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    Fig. 4.

    Effective fraction of inspired oxygen (effective FIO2) versus oxygen flow rate with 2 different oxygen supply systems (membrane separator and molecular sieve) and 2 different oxygen delivery systems (nasal cannula and transtracheal catheter). Data are expressed as mean ± SEM.

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    Fig. 5.

    PaO2 versus oxygen flow. A: Data from all 10 subjects while receiving oxygen only via nasal cannula. B: Data from the 4 subjects who had transtracheal catheter, while they received oxygen only via nasal cannula, and while they received oxygen only via transtracheal catheter. Data are expressed as mean ± SEM.

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Respiratory Care: 55 (4)
Respiratory Care
Vol. 55, Issue 4
1 Apr 2010
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Effective Inspired Oxygen Concentration Measured Via Transtracheal and Oral Gas Analysis
Gerald H Markovitz, James Colthurst, Thomas W Storer, Christopher B Cooper
Respiratory Care Apr 2010, 55 (4) 453-459;

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Effective Inspired Oxygen Concentration Measured Via Transtracheal and Oral Gas Analysis
Gerald H Markovitz, James Colthurst, Thomas W Storer, Christopher B Cooper
Respiratory Care Apr 2010, 55 (4) 453-459;
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