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Research ArticleOriginal Research

Evaluation of Aerosol Generator Devices at 3 Locations in Humidified and Non-humidified Circuits During Adult Mechanical Ventilation

Arzu Ari, Hasan Areabi and James B Fink
Respiratory Care July 2010, 55 (7) 837-844;
Arzu Ari
Division of Respiratory Therapy, School of Health Professions, Georgia State University, Atlanta, Georgia.
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  • For correspondence: [email protected]
Hasan Areabi
Division of Respiratory Therapy, School of Health Professions, Georgia State University, Atlanta, Georgia.
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James B Fink
Division of Respiratory Therapy, School of Health Professions, Georgia State University, Atlanta, Georgia.
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    Fig. 1.

    Model of aerosol delivery during adult ventilation, consisting of a dual-chamber test lung, filters, endotracheal tube, ventilator circuit (with and without humidifier and heated wire), and mechanical ventilator. The 3 aerosol generator positions are shown.

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    Fig. 2.

    Mean ± SD inhaled drug mass (mg) with 4 types of aerosol generator, 3 aerosol-generator positions, and with and without heating and humidification of the ventilator circuit. * Significant difference between with and without heating and humidification. † Significant difference between positions with the non-humidified ventilator circuit. ‡ Significant difference between positions with the heated/humidified ventilator circuit.

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    Fig. 3.

    Mean ± SD inhaled drug mass (mg) in each position, comparing the 4 aerosol generators with and without heating and humidification of the ventilator circuit. * Significant difference with the unheated ventilator circuit. ‡ Significant difference with the heated ventilator circuit

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Respiratory Care: 55 (7)
Respiratory Care
Vol. 55, Issue 7
1 Jul 2010
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Evaluation of Aerosol Generator Devices at 3 Locations in Humidified and Non-humidified Circuits During Adult Mechanical Ventilation
Arzu Ari, Hasan Areabi, James B Fink
Respiratory Care Jul 2010, 55 (7) 837-844;

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Evaluation of Aerosol Generator Devices at 3 Locations in Humidified and Non-humidified Circuits During Adult Mechanical Ventilation
Arzu Ari, Hasan Areabi, James B Fink
Respiratory Care Jul 2010, 55 (7) 837-844;
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Keywords

  • aerosols
  • jet nebulizer
  • vibrating-mesh nebulizer
  • ultrasonic nebulizer
  • metered-dose inhaler
  • pMDI
  • ventilator circuit
  • mechanical ventilation
  • heat
  • humidity
  • drug administration
  • aerosol drug deposition
  • nebulizers

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