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Research ArticleOriginal Research

Aerosol Delivery and Humidification With the Boussignac Continuous Positive Airway Pressure Device

Arnaud W Thille, Jean-François Bertholon, Marie-Hélène Becquemin, Monique Roy, Aissam Lyazidi, François Lellouche, Esther Pertusini, Georges Boussignac, Bernard Maître and Laurent Brochard
Respiratory Care October 2011, 56 (10) 1526-1532; DOI: https://doi.org/10.4187/respcare.00847
Arnaud W Thille
Medical Intensive Care Unit, Assistance Publique-Hôpitaux de Paris, Henri Mondor Hospital, University of Paris Est, Créteil, France.
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  • For correspondence: [email protected]
Jean-François Bertholon
Department of Respiratory Physiology, Assistance Publique-Hôpitaux de Paris, Saint-Antoine Hospital, Paris, Pierre et Marie Curie University, Paris, France.
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Marie-Hélène Becquemin
Service d'Explorations Fonctionnelles Respiratoires, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France.
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Monique Roy
Laboratoire de Granulométrie et de Dépôt des Aérosols, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France.
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Aissam Lyazidi
Medical Intensive Care Unit, Assistance Publique-Hôpitaux de Paris, Henri Mondor Hospital, University of Paris Est, Créteil, France.
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François Lellouche
Medical Intensive Care Unit, Assistance Publique-Hôpitaux de Paris, Henri Mondor Hospital, University of Paris Est, Créteil, France.
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Esther Pertusini
Medical Intensive Care Unit, Assistance Publique-Hôpitaux de Paris, Henri Mondor Hospital, University of Paris Est, Créteil, France.
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Georges Boussignac
Medical Intensive Care Unit, Assistance Publique-Hôpitaux de Paris, Henri Mondor Hospital, University of Paris Est, Créteil, France.
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Bernard Maître
Department of Pulmonology, Assistance Publique-Hôpitaux de Paris, Henri Mondor Hospital, Créteil Intercommunal Hospital, University of Paris Est, Créteil, Créteil, France.
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Laurent Brochard
Medical Intensive Care Unit, Assistance Publique-Hôpitaux de Paris, Henri Mondor Hospital, University of Paris Est, Créteil, France.
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    Fig. 1.

    The Boussignac continuous positive airway pressure (CPAP) is a small plastic cylinder that attaches to a face mask. The distal connector at the device's open end connects to the driving gas (air or O2), and the proximal connector on the patient side allows either oxygen supplementation or mask-pressure measurement.

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    Fig. 2.

    Setup for aerosol particle size measurement. A: Boussignac continuous positive airway pressure (CPAP) device, connected to a compressed air source. B: Heat-and-moisture exchanger. C: T-piece. D: Nebulizer. E: T-piece. F: Laser diffraction particle sizer and counter. G: Ventilator circuit, leading to a pump.

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    Fig. 3.

    Relationship between the nebulizer driving gas flow and continuous positive airway pressure (CPAP) generated in the mask, with the Boussignac CPAP system during inspiration, expiration, or without CPAP.

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    Fig. 4.

    Absolute humidity during the tested ventilation conditions. Continuous positive airway pressure (CPAP) was driven with dry compressed air. Adequate humidification was provided with heat-and-moisture exchanger (HME) or heated humidifier.

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    Fig. 5.

    A: Work of breathing before and after nebulized terbutaline delivered via standard nebulization method versus delivered during continuous positive airway pressure (CPAP). WOB decreased similarly with the 2 methods (P = .06). B: PaO2 and PaCO2 after nebulized terbutaline delivered via standard nebulization method versus delivered during CPAP. PaO2 was significantly higher with CPAP nebulization. PaCO2 was not significantly different between the 2 methods.

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Respiratory Care: 56 (10)
Respiratory Care
Vol. 56, Issue 10
1 Oct 2011
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Aerosol Delivery and Humidification With the Boussignac Continuous Positive Airway Pressure Device
Arnaud W Thille, Jean-François Bertholon, Marie-Hélène Becquemin, Monique Roy, Aissam Lyazidi, François Lellouche, Esther Pertusini, Georges Boussignac, Bernard Maître, Laurent Brochard
Respiratory Care Oct 2011, 56 (10) 1526-1532; DOI: 10.4187/respcare.00847

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Aerosol Delivery and Humidification With the Boussignac Continuous Positive Airway Pressure Device
Arnaud W Thille, Jean-François Bertholon, Marie-Hélène Becquemin, Monique Roy, Aissam Lyazidi, François Lellouche, Esther Pertusini, Georges Boussignac, Bernard Maître, Laurent Brochard
Respiratory Care Oct 2011, 56 (10) 1526-1532; DOI: 10.4187/respcare.00847
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Keywords

  • continuous positive airway pressure
  • CPAP
  • work of breathing
  • aerosol therapy
  • β2-agonist
  • bronchodilator
  • heat-and-moisture exchanger
  • heated humidifier

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