Abstract
BACKGROUND: Chair-sitting may allow for more readily activated scalene, sternocleidomastoid, and parasternal intercostal muscles, and may raise and enlarge the upper thoracic cage, thereby allowing the thoracic cage to be more easily compressed.
OBJECTIVE: To evaluate the effect of chair-sitting during exercise training on respiratory muscle function in mechanically ventilated patients.
METHODS: We randomized 16 patients to a control group and 18 patients to a chair-sitting group. The patients in the chair-sitting group were transferred by 2 intensive care unit nurses from bed to armchair and rested for at least 30 min, based on the individual patient's tolerance. We measured heart rate, blood pressure, SpO2, and respiratory rate. In the treatment group, before transferring the patient from bed to armchair, and 30 min after the completion of chair-sitting we measured respiratory muscle function variables, including the ratio of respiratory rate (f) to tidal volume (VT), SpO2, maximum inspiratory pressure (PImax) and maximum expiratory pressure (PEmax). In the control patients we took those same measurements while the patient was in semirecumbent position, before and after treatments, for at least 6 days or until the patient was discharged from the intensive care unit or died.
RESULTS: The 2 groups did not significantly differ in age, sex, or clinical outcomes. Respiratory rate, VT, f/VT, SpO2, PImax, and PEmax were not significantly better in the chair-sitting group. The study period significantly improved respiratory rate, VT, PImax, and PEmax (all P < .001), but not f/VT.
CONCLUSIONS: Six days of chair-sitting exercise training did not significantly improve respiratory muscle function in mechanically ventilated patients.
Introduction
The lack of physical activity in mechanically ventilated critically ill patients reduces respiratory muscle strength1 and may prolong ventilator dependence and intensive care unit (ICU) stay. Early physiotherapy, including positioning (eg, upright, prone, or side lying position) and mobilization (eg, getting out of bed via mechanical lifting machine, sitting on the edge of the bed, standing, transferring from bed to chair, and walking), have been advocated to prevent skeletal muscle weakness, reduce the work of breathing, and shorten mechanical ventilation in the ICU.2–5 An early study indicated that vital capacity decreased following a change of position from sitting to supine position.6 Patients with chronic asthma had significantly higher maximum expiratory pressure (PEmax) in a sitting leaning-forward position than in the supine position (P < .001).7 Jenkins et al8 studied the effects of positioning on functional residual capacity in normal subjects and in male patients before and after coronary artery surgery. In the normal subjects and patients, functional residual capacity was higher in the chair-sitting position than the lying position.8 However, other studies found that the upright sitting position did not improve tidal volume (VT), total lung capacity, or functional residual capacity in intubated subjects with abdominal distention, ascites, or obesity,9 and healthy individuals.10
Chair-sitting (ie, transferring from bed to chair and sitting) combines both positioning and mobilization techniques, and we have applied this technique in our surgical ICU to improve mechanically ventilated patients' respiratory muscle strength. Theoretically, chair-sitting could help the scalene, sternocleidomastoid, and parasternal intercostal muscles be more readily activated, and could raise and enlarge the upper thoracic cage, thereby allowing the thoracic cage to be more easily compressed and increasing PEmax.10 However, there have been few studies on the efficacy of this physiotherapy on respiratory muscle and weaning outcomes in the ICU. We conducted a randomized controlled trial to evaluate the effect of chair-sitting on the respiratory muscles of mechanically ventilated patients in a surgical ICU, and hypothesized that the chair-sitting technique would benefit their respiratory muscle function.
Methods
This study was approved by the institutional review board of Taichung Veterans General Hospital. Informed consent was obtained from all patients and/or their legal representatives.
Study Design
This was a prospective randomized controlled study, conducted in a 24-bed surgical ICU at Taichung Veterans General Hospital, which is a 1,359-bed medical center in central Taiwan.
Patients
All patients admitted or transferred to the surgical ICU were screened for potential study participation. Patients who required mechanical ventilation for at least 72 hours and who could be transferred by 2 surgical ICU nurses from bed to armchair without a mechanical lifting machine were considered for enrollment. The patients were orally intubated with a cuffed endotracheal tube (inner-diameter range 7–8 mm) and mechanically ventilated (840, Puritan Bennett, Carlsbad, California) in a volume or pressure ventilation mode, with a decremental inspiratory flow. Applied PEEP was titrated to 3–5 cm H2O to maintain the elastic recoil pressure of the respiratory system, so the physiologic PEEP was kept constant throughout the study. The peak airway pressure was kept between 30 and 40 cm H2O, to prevent ventilator-induced lung injury.
We excluded patients who were under 18 years old, clinically unstable, unconscious, had received neurosurgery or cardiovascular surgery, had self-extubated, had postoperative abdominal wound dehiscence, or had received a tracheostomy. At enrollment we recorded age, sex, height, diagnosis, and Acute Physiology and Chronic Health Evaluation II (APACHE II) score. During the study we daily measured patient weight and calculated body mass index. From the medical records we obtained ICU and hospital stay and ventilator days.
Intervention
Thirty-four patients were randomly assigned to either the control group (n = 16) or the treatment (chair-sitting) group (n = 18). The random assignment was based on a computerized randomization scheme with sealed opaque envelopes. All interventions were performed for at least 6 days, or until the patient was discharged from the ICU or died. If a patient was weaned or discharged from the ICU earlier than 6 days, each measurement would be treated as a missing value. Patients in the control group were requested to lie in a comfortable position in between the supine and the semirecumbent position, and none of the control patients received any type of physical therapy during the study. Patients in the chair-sitting group were transferred by 2 ICU nurses from bed to armchair and rested for at least 30 min to a maximum of 120 min, based on each patient's tolerance. We did not use a mechanical lifting machine. In the 18 patients randomized to the intervention group, the chair-sitting technique was performed at least once a day in 15 patients, and a minimum of 3 times a week in 3 patients. Before each mobilization, analgesia was given if needed.
Measurements
In the treatment group, outcome measurements were taken before transferring the patient from bed to armchair, and 30 min after the completion of chair-sitting. In the control group, measurements were taken with the patient in the semirecumbent position, before and after treatment times, similar to those of the treatment group. The primary outcome of respiratory muscle endurance was measured with the rapid shallow breathing index, which is the ratio of spontaneous breathing frequency to VT (f/VT), a reliable predictor of weaning success.11 The secondary outcomes were VT and respiratory muscle strength, measured as inspiratory muscle strength (maximum inspiratory pressure, PImax), and PEmax. VT and f were measured with a hand-held respirometer (Haloscale Wright Respirometer, Ferraris Respirometer, Cardinal Health, Dublin, Ohio) while each patient temporarily breathed through a T-piece setup for 60 seconds. Maximum negative inspiratory pressure and PEmax were measured with an aneroid manometer while the patient performed maximum static inspiratory and expiratory efforts against an occluded airway.12 Heart rate, systolic and diastolic blood pressure, SpO2, and respiratory rate were continuously measured (Intellivue Patient Monitor, Phillips Medizin System, Boeblingen, Germany) while the patient was in the chair-sitting position.
Statistical Analysis
An f/VT difference of 20 has been observed between extubation success (62 ± 29) and extubation failure (82 ± 15) patients.13 A sample size of 16 patients was therefore required in each group to demonstrate a f/VT difference of 20 with a statistical power of 80% and a 2-sided α level of < .05.
Data were analyzed with statistics software (SigmaStat 2.03, Jandel Scientific, San Rafael, California). In the statistical analysis, missing values were obtained from the previous measured value. Differences in demographic data and clinical outcomes were analyzed with the Student t test. If data were skewed rather than normally distributed, we calculated the differences with the Mann-Whitney rank sum test. We assessed categorical response variables with the chi-square test, and with the Fisher exact test if the expected frequency was < 5. We used the paired the Student t test to compare the differences in clinical outcomes and respiratory muscle function before and after treatment. We used linear mixed models to evaluate the effect of treatment and study period, and the interaction of treatment and study period on clinical outcomes and respiratory muscle function. Differences were considered statistically significant when P < .05. Values are presented as means ± SD.
Results
Subjects
Of the 180 patients in the surgical ICU who were screened for eligibility, 143 failed to meet the entry criteria. The remaining 34 patients (21 males, 13 females) were randomly assigned to either the treatment (chair-sitting) or the control group (Fig. 1 and Table 1). The mean age was 66.1 y (range 34–89 y). The mean ICU ventilator days was 6.7 d (range 3–24 d). Mean ICU stay was 17.5 d (range 6.0–41.5 d). The chair-sitting and control groups did not differ in any demographic or clinical variables, including age, sex, blood pressure, APACHE II score, ICU stay, ICU ventilator days, weaning or re-intubation rate, comorbidities, diagnosis, and complications. None of the treatment-group patients received analgesia before the bed-to-chair mobilizations. The most common diagnoses at ICU admission were gastrointestinal bleeding, peritonitis, trauma, and cancer of the colon, kidney, bladder, esophagus, or lung. The most common comorbidities were heart failure, pulmonary edema, asthma, and COPD.
Flow chart. ICU = intensive care unit.
Subjects (n = 34)
Responses of Respiratory Muscle Function to Position Changes
Table 2 summarizes the results. Before the treatment on day 1, there were no significant differences in the clinical outcomes (ie, heart rate, systolic and diastolic blood pressure) or respiratory muscle function variables (ie, respiratory rate, VT, f/VT, SpO2, PImax, or PEmax) between the 2 groups. Only heart rate significantly increased after chair-sitting training on day 2 through day 5. Respiratory muscle function had improved slightly but not significantly after 6 days of the chair-sitting intervention. The linear mixed models indicated that respiratory rate, VT, f/VT, PImax, and PEmax were significantly affected by the study period, but not with regard to chair-sitting training.
Physiologic Variables in Chair-Sitting Group Versus Control Group
Discussion
Reduced respiratory muscle strength is a common problem in ventilator-dependent patients. Muscle weakness occurs in a quarter of ICU patients mechanically ventilated for ≥ 7 days.14 Although physiotherapy in mechanically ventilated critically ill patients has a sound physiologic rationale, there are few published data to support its efficacy in the critical care setting. To the best of our knowledge, there are no reported data on the effect of chair-sitting on respiratory muscle function in mechanically ventilated post-surgical ICU patients. We found that chair-sitting training slightly but not significantly improved respiratory muscle function. However, the study period (days of treatment) could be a factor that affects patients' respiratory muscle function.
Respiratory muscle strength can be improved by muscle training in mechanically ventilated patients.15,16 In patients who had failed weaning attempts and underwent respiratory-muscle resistive training, mean PImax improved 42%, from 38 cm H2O to 54 cm H2O.15 In our study, however, mean PImax improved not only in our patients with chair-sitting training but also in the control patients, and the magnitude of the improvement was even higher in the control group (61% vs 106%). The lack of improvement of respiratory muscle function in our chair-sitting treatment group might be due to their low illness severity (mean APACHE II score 17.3) at admission, and the patients had optimistic SpO2, PImax, and PEmax values when they started the chair-sitting training. In addition, the weaning rate was high. Although we anticipated that chair-sitting training would improve respiratory muscle function in our patients with an optimistic clinical condition, it is possible that medical intervention time rather than additional training was the cause of their improved respiratory muscle function.
Chair sitting did not significantly improve inspiratory muscle strength in our patients. Caruso et al17 indicated that overtraining and fatigue might be causes of ineffective inspiratory muscle training in mechanically ventilated critically ill patients. However, fatigue may not have been the confounder in our study. Our patients were transferred from bed to chair and sitting with only brief training. In addition, outcomes were measured before and after the treatment, and the results were similar. With regard to training load, we monitored the patients' heart rate and systolic and diastolic blood pressure throughout the study. In contrast to the results of a previous study,13 we found a significant increase in heart rate only when systolic and diastolic blood pressure were not significantly different before and after training. A previous study also found that mobilization (ie, sitting on the edge of the bed, sitting to standing, a standing transfer from the edge of the bed to a chair or walking) significantly increased heart rate and blood pressure and caused a nonsignificant SpO2 decrease in acutely ill patients. However, those changes were generally of small magnitude and did not require any specific intervention.18 The change in heart rate seems to be of minor clinical importance. Overtraining, therefore, can be ruled out.
In the clinical setting, a reduction in VT is associated with a gradual increase in respiratory rate, which generates dynamic pulmonary hyperinflation and worsens muscle contractility.19,20 An f/VT of < 105 is used as a measure of rapid and shallow breathing20,21 and has been a useful index for predicting weaning outcome.10 f/VT is significantly higher in patients who failed weaning.21–23 Although there was no significant difference in weaning rate between the 2 groups, chair-sitting training was associated with a significant f/VT increase in our patients. Chair-sitting training, therefore, had no benefit on our patients' respiratory muscle function and might induce an increase in mechanical load to breathe in mechanically ventilated ICU patients.
Limitations
Our sample size was small. Although we calculated the required sample size prior to the study, and the patients in the chair-sitting group had a slight improvement in respiratory muscle function, the fact that the control patients tended to show a similar improvement suggested that chair-sitting did not provide any benefit. Age is probably the main confounder to affect the outcomes. Although there was no significant difference in age between the 2 groups, we still adjusted for age when discussing the data (see Table 2), so the difference was not expected to affect the study results. Another limitation was the short duration of the training. Although our patients' mean f/VT did not reach the optimal value (< 105) after 6 days of chair-sitting training, there was a 9.8% f/VT reduction. Although a reasonable training period has not been determined for ventilated ill patients, 6 weeks of physical training does significantly improve respiratory and limb muscle strength in patients on prolonged mechanical ventilation.24 Six days of training may not have been sufficient to determine the effect in our patients. A longer training period might significantly improve ventilated patients' respiratory muscle function. The third limitation might be that the intervention was not optimally controlled: the treatments ranged from 30 min to 120 min, and not all patients received at least once-a-day chair-sitting training. That treatment variation might be too large to allow us to identify a significant effect from the chair-sitting training. A fourth limitation might be that the measurements were made a short time after the completion of the mobilization treatment. In order to avoid measuring any possible immediate, short-term adverse effects from the mobilization treatment, we took the measurements 30 min after treatment. The fifth limitation was the blinding. Although this was a randomized controlled trial, the clinicians were not blinded to group assignment. It is possible that the clinicians or patients may have been more motivated in performing chair-sitting training. However, the Hawthorne effect could not have occurred, since the results did not support a benefit from chair-sitting training. Finally, we had no “positive” control group (ie, that received other physical therapy), so our finding is only that chair-sitting training was not significantly different from no chair-sitting treatment, and we do not know how the chair-sitting intervention would compare to other respiratory-muscle physiotherapy in mechanically ventilated patients.
Conclusions
Our ICU patients' respiratory rate, VT, f/VT, SpO2, PImax, and PEmax were not significantly improved after 6 days of chair-sitting training, compared to the control patients who received no physiotherapy treatment. Six days of chair-sitting training was ineffective for improving respiratory muscle function in mechanically ventilated ICU patients. However, these results do not justify decreased use of ICU physical therapy. More studies are needed on the effect of position change on respiratory muscle function. Respiratory-specific physical therapies, such as paced breathing trials and diaphragm strengthening, might provide greater benefit for mechanically ventilated patients.
Footnotes
- Correspondence: Chien-Hsiang Cheng MD PhD, Department of Critical Care, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China. E-mail: ych{at}csmu.edu.tw.
This study was partly supported by grant TCVGH-967420A from the Taichung Veterans General Hospital, Taichung, Taiwan.
The authors have disclosed no conflicts of interest.
- Copyright © 2011 by Daedalus Enterprises Inc.
References
