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Case ReportCase Reports

Relationship Between Diffuse Pulmonary Fibrosis, Alveolar Proteinosis, and Granulocyte-Macrophage Colony Stimulating Factor Autoantibodies

Maurizio Luisetti, Pierdonato Bruno, Zamir Kadija, Takuji Suzuki, Salvatore Raffa, Maria Rosaria Torrisi, Ilaria Campo, Francesca Mariani, Ernesto Pozzi, Bruce C Trapnell and Salvatore Mariotta
Respiratory Care October 2011, 56 (10) 1608-1610; DOI: https://doi.org/10.4187/respcare.01054
Maurizio Luisetti
Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo Foundation, Pavia, Italy.
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Pierdonato Bruno
Unità Operativa Complessa Pneumologia and Diagnostica Cellulare, Medicina Clinica e Molecolare, Azienda Ospedaliera Sant' Andrea, Università di Roma La Sapienza, Roma, Italy.
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Zamir Kadija
Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo Foundation, Pavia, Italy.
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Takuji Suzuki
Division of Pulmonary Biology, Department of Pulmonary, Critical Care, and Sleep Medicine, Cincinnati Children's Hospital Medical Center Cincinnati, Ohio.
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Salvatore Raffa
Unità Operativa Complessa Pneumologia and Diagnostica Cellulare, Medicina Clinica e Molecolare, Azienda Ospedaliera Sant' Andrea, Università di Roma La Sapienza, Roma, Italy.
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Maria Rosaria Torrisi
Unità Operativa Complessa Pneumologia and Diagnostica Cellulare, Medicina Clinica e Molecolare, Azienda Ospedaliera Sant' Andrea, Università di Roma La Sapienza, Roma, Italy.
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Ilaria Campo
Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo Foundation, Pavia, Italy.
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  • For correspondence: [email protected]
Francesca Mariani
Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo Foundation, Pavia, Italy.
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Ernesto Pozzi
Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo Foundation, Pavia, Italy.
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Bruce C Trapnell
Division of Pulmonary Biology, Department of Pulmonary, Critical Care, and Sleep Medicine, Cincinnati Children's Hospital Medical Center Cincinnati, Ohio.
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Salvatore Mariotta
Unità Operativa Complessa Pneumologia and Diagnostica Cellulare, Medicina Clinica e Molecolare, Azienda Ospedaliera Sant' Andrea, Università di Roma La Sapienza, Roma, Italy.
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References

  1. 1.↵
    1. Sakagami T,
    2. Uchida K,
    3. Suzuki T,
    4. Carey BC,
    5. Wood RE,
    6. Wert SE,
    7. et al
    . Human GM-CSF autoantibodies and reproduction of pulmonary alveolar proteinosis. N Engl J Med 2009;361(27):2679–2681.
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  2. 2.↵
    1. Trapnell BC,
    2. Carey BC,
    3. Uchida K,
    4. Suzuki T
    . Pulmonary alveolar proteinosis, a primary immunodeficiency of impaired GM-CSF stimulation of macrophages. Curr Opin Immunol 2009;21(5):514–521.
    OpenUrlCrossRefPubMedWeb of Science
  3. 3.↵
    1. Trapnell BC,
    2. Whitsett JA,
    3. Nakata K
    . Pulmonary alveolar proteinosis. N Engl J Med 2003;349(26):2527–2539.
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  4. 4.↵
    1. Holbert JM,
    2. Costello P,
    3. Li W,
    4. Hoffman RM,
    5. Rogers RM
    . CT features of pulmonary alveolar proteinosis. AJR Am J Roentgenol 2001;176(5):1287–1294.
    OpenUrlPubMedWeb of Science
  5. 5.↵
    1. Whitsett JA,
    2. Wert SE,
    3. Weaver TE
    . Alveolar surfactant homeostasis and the pathogenesis of pulmonary disease. Annu Rev Med 2010;61:105–119.
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  6. 6.↵
    1. Chroneou A,
    2. Zias N,
    3. Tronic BS,
    4. Gonzalez AV,
    5. Beamis GF
    . A case of uncomplicated pulmonary alveolar proteinosis evolving to pulmonary fibrosis. Monaldi Arch Chest Dis 2007;67(4):234–237.
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  7. 7.↵
    1. Inoue Y,
    2. Trapnell BC,
    3. Tazawa R,
    4. Arai T,
    5. Takada T,
    6. Hizawa N,
    7. et al
    . Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan. Am J Respir Crit Care Med 2008;177(7):752–762.
    OpenUrlCrossRefPubMedWeb of Science
  8. 8.↵
    1. Uchida K,
    2. Nakata K,
    3. Suzuki T,
    4. Luisetti M,
    5. Watanabe M,
    6. Koch DE,
    7. et al
    . Granulocyte/macrophage colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy individuals. Blood 2009;113(11):2547–2556.
    OpenUrlAbstract/FREE Full Text
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Respiratory Care: 56 (10)
Respiratory Care
Vol. 56, Issue 10
1 Oct 2011
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Relationship Between Diffuse Pulmonary Fibrosis, Alveolar Proteinosis, and Granulocyte-Macrophage Colony Stimulating Factor Autoantibodies
Maurizio Luisetti, Pierdonato Bruno, Zamir Kadija, Takuji Suzuki, Salvatore Raffa, Maria Rosaria Torrisi, Ilaria Campo, Francesca Mariani, Ernesto Pozzi, Bruce C Trapnell, Salvatore Mariotta
Respiratory Care Oct 2011, 56 (10) 1608-1610; DOI: 10.4187/respcare.01054

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Relationship Between Diffuse Pulmonary Fibrosis, Alveolar Proteinosis, and Granulocyte-Macrophage Colony Stimulating Factor Autoantibodies
Maurizio Luisetti, Pierdonato Bruno, Zamir Kadija, Takuji Suzuki, Salvatore Raffa, Maria Rosaria Torrisi, Ilaria Campo, Francesca Mariani, Ernesto Pozzi, Bruce C Trapnell, Salvatore Mariotta
Respiratory Care Oct 2011, 56 (10) 1608-1610; DOI: 10.4187/respcare.01054
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Keywords

  • pulmonary fibrosis
  • pulmonary alveolar proteinosis
  • alveolar surfactant
  • granulocyte-macrophage colony stimulating factor
  • surfactant catabolism
  • lamellar bodies
  • idiopathic interstitial pneumonia

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