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Research ArticleOriginal Research

Leak Profile Inspection During Nasal Continuous Positive Airway Pressure

Marcel A Baltzan, Richard Dabrusin, Alfonso Garcia-Asensi, Jennie-Laure Sully, Maryse Parenteau, Germaine Tansimat, Ibrahim Kassissia and Norman Wolkove
Respiratory Care May 2011, 56 (5) 591-595; DOI: https://doi.org/10.4187/respcare.00977
Marcel A Baltzan
Mount Sinai Hospital Center, Montréal, Québec, Canada.
OSR Médical Sleep Disorders Center, Montréal, Québec, Canada.
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  • For correspondence: [email protected]
Richard Dabrusin
Mount Sinai Hospital Center, Montréal, Québec, Canada.
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Alfonso Garcia-Asensi
OSR Médical Sleep Disorders Center, Montréal, Québec, Canada.
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Jennie-Laure Sully
Mount Sinai Hospital Center, Montréal, Québec, Canada.
Université de Montréal, Montréal, Québec, Canada.
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Maryse Parenteau
OSR Médical Sleep Disorders Center, Montréal, Québec, Canada.
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Germaine Tansimat
OSR Médical Sleep Disorders Center, Montréal, Québec, Canada.
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Ibrahim Kassissia
OSR Médical Sleep Disorders Center, Montréal, Québec, Canada.
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Norman Wolkove
Mount Sinai Hospital Center, Montréal, Québec, Canada.
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Abstract

BACKGROUND: Patients treated with nasal continuous positive airway pressure (nasal CPAP) for obstructive sleep apnea (OSA) often have adverse effects from and poor adherence to CPAP.

OBJECTIVE: To describe abnormal CPAP leak profiles and assess inter-observer reliability in identifying leak profiles and the correlation of leak profiles with leak rate and clinical outcomes.

METHODS: In a sleep-disorders clinic we prospectively studied 35 consecutive patients newly diagnosed with moderate or severe OSA, and who had undergone polysomnographic diagnosis and nasal CPAP titration. We analyzed the data recorded by their CPAP machines during their first week of CPAP. Two independent clinical sleep specialists inspected each night's leak profiles. We defined a “continuous” leak profile segment as a leak increase of ≥ 20 L/min for > 5 min. We defined a “serrated” leak profile segment as a leak that oscillated up to ≥ 20 L/min in ≤ 5 min. With a validated questionnaire, we surveyed the patients about adverse effects.

RESULTS: Overall inter-observer agreement was 88% for continuous leak and 92% for serrated leaks. The kappa values were 0.76 and 0.85, respectively. Deviance (± 2 SD) between scorers was −14% to 11% for continuous leaks, and −15% to 9% for serrated leaks. The duration of manually scored profiles correlated modestly but significantly with the machine-recorded leaks. The mean ± SD adherence to CPAP was lower in the patients with the highest quartile of continuous leak (5.28 ± 2.24 h/night versus 6.66 ± 1.72 h/night). Adverse effects increased with increasing serrated leak (P = .01).

CONCLUSIONS: Manually scored leak profiles in patients treated with nasal CPAP can guide clinicians with respect to short-term adherence to nasal CPAP and adverse effects.

  • sleep apnea
  • sleep apnea syndromes
  • polysomnography
  • continuous positive airway pressure
  • CPAP

Introduction

The most commonly used therapy for obstructive sleep apnea (OSA) is continuous positive airway pressure (CPAP).1–4 This is usually administered via nasal mask (nasal CPAP), which is perceived as more comfortable than oronasal mask.5 Adverse effects are common,6–10 and overall adherence to CPAP therapy is poor, because patients often abandon therapy within the first month.11–14

The monitoring of CPAP therapy is now possible with the advent of CPAP machines that gather statistical and graphical information on use and efficacy. Current CPAP machines collect data on time-at-pressure, apneas, hypopneas, snoring, and leaks, and those data are important in clinical follow-up, especially if the patient initiated on auto-titrating CPAP, without polysomnographic titration.15 Current CPAP machines can also create graphic profiles that describe the data. However, the utility of this wealth of information is unclear. Studies to correlate the CPAP machine data with adverse effects and adherence to therapy are lacking. Specifically, it has not been established that the data collected provides information that allows clinicians to modify CPAP. The use of such information shows promise in improving patient care.16

Based on our clinical observations, we postulated that OSA patients on nasal CPAP have discernible leak patterns that can be reliably interpreted. These leak patterns may reflect phenomena that impact patient adverse effects, adherence to therapy, and patient satisfaction with nasal CPAP. To test this hypothesis we first explored a group of consecutive subjects who were starting nasal CPAP treatment. Our primary goal was to describe and evaluate 2 types of leak patterns. We studied inter-scorer concordance in profile interpretation, and correlated machine-recorded leaks with the duration of the profile ratings. To explore the potential meaning of these profiles, we also administered a questionnaire to patients to determine whether patient satisfaction and adverse effects were related to these pressure profiles. We also studied the relationship of the leak profiles to CPAP adherence.

Methods

Study Design

We prospectively studied consecutive newly diagnosed patients who were prescribed single-pressure nasal CPAP. All the patients were recruited from the specialized out-patient sleep clinic of Mount Sinai Hospital Center, Montreal, Québec, Canada. The study was approved by the Mount Sinai Hospital ethics committee, and we followed the ethical standards prescribed by Québec law and the Declaration of Helsinki.

A group of 35 consecutive patients qualified out of a consecutive recruitment of 79 patients. Among those not included were 9 whose CPAP was titrated with an oronasal mask; 10 men who had upper-lip facial hair (moustaches), which is expected to cause leak at the mask interface; 23 patients who were not committed to using CPAP; and 12 who declined consent for personal reasons, including time and travel constraints.

Inclusion in the study required verification of the OSA diagnosis, with an apnea-hypopnea index of > 15 events per hour, via polysomnography. If central apneas were scored, more obstructive rather than central apneas were required to be present, with a central apnea index of less than 5 apneas per hour. We excluded patients with severe cardio-respiratory or neurologic disease, variable-pressure therapy, or supplemental oxygen. Patients were evaluated for the study after their first week on nasal CPAP at home, and up to 7 more times over their first 3 months of nasal CPAP, for education and mask fitting, and were offered a change of nasal mask if they sensed the fit was not adequate. They also underwent weekly monitoring of leak, event, and adherence during the first 4 weeks and at the end of 3 months. The data used for the present analyses were from the data download after the first week of nasal CPAP. No external measure of leak was added to the protocol, as we intended to target the clinical population with minimal experimental instrumentation, not to measure the nasal CPAP leak per se, but to analyze the profiles for potentially clinically relevant patterns.

Leak Profile Scoring

Based on clinical experience, 2 distinct leak patterns were selected. A “continuous” leak profile segment was defined as a rapid leak increase of ≥ 20 L/min, above baseline leak, that was sustained for ≥ 5 min. We defined a “serrated” leak profile segment as a leak that oscillated up to ≥ 20 L/min in ≤ 5 min. We observed that the absolute level of leak with a properly applied mask depends on the mask whisper valve characteristics, the CPAP pressure, and perhaps other mechanical mask characteristics. As a result, we did not seek to score the absolute leak values, but instead the relative leak changes during the unsupervised home use periods. We chose the 20 L/min cut-off because it was a clearly discernible change on the tracings, and was found to be a threshold that may require attention during positive airway titration polysomnography.

Two independent clinical sleep specialists reviewed the leak profiles by independent inspection of each night's recordings after the first week of treatment. They scored the tracings via visual inspection, based on the a priori defined and written criteria. Each night was scored independently. For each night both scorers determined the percentage of time in the 2 patterns, which was immediately recorded as a percentage on a separate scoring sheet for later inter-scorer comparison. The scorers were blinded to each other's scoring. Scores were deemed to agree if they were within 10%. For correlation with machine leak statistics, adverse effects, and adherence, average leak pattern percentages were calculated for each patient. A night was disqualified if less than 2 hours were recorded.

Measurements

We evaluated several CPAP machines for possible use in this study, and chose the REMStar (Respironics, Murrysville, Pennsylvania) because it provided the longest period of full data collection (7 days of graphic leak profiles) and several leak and adherence statistics.

We investigated the relationship of the leak profiles with adverse effects and satisfaction with CPAP. The adverse effects questionnaire we used has been validated.10 The questions are on a 7-point ordinal scale, and the respondent self-rates the frequency of morning headache, morning dry mouth, nasal congestion, rhinorrhea, and air leak out the mouth. Overall satisfaction with CPAP treatment is rated on a zero (not at all satisfied) to 10 (extremely well satisfied) scale.

Nocturnal diagnostic polysomnography had been performed on all the patients. Sleep staging was performed with the standard polysomnographic montage (C3, C4, O1, O2, electrooculogram, and electroencephalogram). Additional measurements included air flow (measured via nasal pressure transducer and thermistor), thoraco-abdominal movements (measured via inductive plethysmography), and pulse oximetry. Registered polysomnographic technologists scored the studies, using standard criteria.17–19

Statistical Analysis

The primary analysis of inter-scorer agreement was calculated on a per-night basis for each of the leak profiles. We calculated the kappa values, percent agreement, and deviance between scorers.20 We also calculated the correlations between the week's leak profile averages and the leak statistics generated by the CPAP machine, which also compiled machine-measured variables over the data-collection week. We initially analyzed the adverse effects, CPAP adherence, and patient satisfaction by graphing in quartiles for visual inspection of linearity, prior to statistical analysis. We performed statistical tests of associations with a t test for continuous variables. Statistical significance was declared at a 2-sided P < .05. For the multiple planned comparisons of both manually scored leak profiles with overall adverse effects, adherence, and satisfaction, we made a Bonferroni adjustment to state significance with a significant P < .008. A power analysis estimated that at least 31 patients with a specific leak profile were required to detect a one-hour reduction in adherence to a beta error of 0.80. A post-hoc calculation revealed that the final power of the study was over 0.95.

Results

Table 1 describes the patients. Leak profiles could clearly be scored on the tracings (Fig. 1). Table 2 shows the machine-measured variables and the manually scored leak times. Overall inter-scorer agreement was 88% for continuous leak (kappa 0.76) and 92% for serrated leaks (kappa 0.85). The ranges (± 2 SD) of inter-scorer deviance were −14% to 11% for continuous leak, and −15% to 9% for serrated leak.

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Table 1.

Subjects

Fig. 1.
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Fig. 1.

Examples of leak profile scoring. Upper panel: continuous leak 0% of the time; serrated leak 0% of the time. Lower panel: continuous leak (at points labeled C) 7% of the time; serrated leak (at points labeled S) 27% of the time.

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Table 2.

Leak Characteristics During the First Week of Nasal CPAP

Table 3 shows the correlations between the manually scored leaks and the machine-recorded leaks. Both the continuous and serrated manually scored leaks correlated moderately with the overall average leak and the average 90% leak.

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Table 3.

Correlation of CPAP-Machine-Recorded Leak and Manually Scored Leak

Adverse effects, as a whole, increased with increasing serrated leak. Adverse effects were more frequent and more severe with increasing serrated leak (P < .001) (Fig. 2). The adverse effect oral air leak also correlated with serrated leak (P = .007). Adverse effects did not correlate with continuous leak (P = .14).

Fig. 2.
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Fig. 2.

Adverse effects of nasal CPAP relative to the quartiles of percent of time with serrated leak profile. There is an increasing frequency of adverse effects with increasing serrated leak time (P < .001).

Adherence did not correlate with serrated leaks (P = .91). The quartile with the higher continuous leak times suggested lower adherence to nasal CPAP (Fig. 3), but that difference did not remain significant after Bonferroni correction.

Fig. 3.
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Fig. 3.

Nasal CPAP adherence with respect to the quartiles of percent of time with continuous leak. * P = .07.

Satisfaction did not correlate with the serrated leak or continuous leak scores (P = .06 and .13, respectively). Patients who sensed leak around the nasal mask and required at least one change of mask type for better fit had, on average, higher continuous leak scores (8.90 SD, 11.0% of time) than those who did not require a change of mask (5.74 SD, 8.29% of time), but that difference did not remain significant after Bonferroni correction.

Discussion

We have shown that the leak profile tracings of patients on nasal CPAP for moderate or severe OSA demonstrate 2 distinct and common patterns we call continuous leak and serrated leak. The leak profile tracings can be reliably scored with explicit criteria, with good inter-scorer agreement. The manually scored leak profile durations correlated modestly with the machine-measured leaks. Adverse effects were higher in patients with more serrated leaks, and the patients with the highest continuous leaks had the worst short-term CPAP adherence.

The majority of patients who are prescribed CPAP for OSA tolerate this therapy and respond well, while others remain on treatment despite adverse effects.5–10 The adequacy and comfort of mask fit, the appropriate pressure, and the management of adverse effects strongly influence efficacy.2,4,21 We believe that any immediately available information that helps improve patient outcomes is valuable. The leak profiles give one clue to difficulties a patient may have with nasal CPAP in their first week. We found that serrated leak is more frequent in patients with greater adverse effects, especially air leak from the mouth. Our finding of a possible relationship between the continuous leak profile and adherence to therapy requires further research, as our statistical analysis may have highlighted a chance finding.

Limitations

We studied only a small number of patients, but this clinical population was carefully selected to be adherent to the protocol to study the leak profiles, including the reliability of visual inspection of the profiles and clinical correlates of these manually scored leak profiles. As a result, the leak frequencies and adverse effects cannot be assumed to be generalizable to all OSA patients. Yet our finding of good inter-scorer agreement and significant correlation with machine-recorded leak statistics supports the internal consistency of this study in distinguishing distinct leak profiles. The next research step would be to monitor patients with attended polysomnography to discern which leak sources resulted in leak profile changes.

Leaks are common in CPAP. Recent guidelines state that these leaks should be minimized with careful mask selection prior to auto-titrating CPAP or manual laboratory titration.15,22 Yet in practice, leaks are very common in patients who sleep with CPAP. The leaks may be due to mask fit problems or, with nasal CPAP, mouth leaks, which have been polysomnographically documented to occur more often in patients with frequent mouth breathing during sleep.23 This phenomenon correlates with worse adherence to nasal CPAP.23 Large leaks can compromise CPAP's effectiveness in treating OSA. When the CPAP machine reads breath-by-breath signals to either trigger ventilatory assistance or modify the pressure at expiration, leak can render these “intelligent” or “triggered” algorithms ineffective and even disrupt sleep.24 We have also found that mouth leak is related to nasal congestion, removal of the nasal CPAP mask, and worse nasal CPAP adherence.10

Conclusions

There are 2 discernible and definable leak patterns in nasal CPAP, serrated leak and continuous leak, which are identifiable with acceptable inter-scorer concordance. There appeared to be a modest correlation of leak pattern duration and overall leak statistics from the CPAP generator. Serrated leak appeared to have a relationship with overall adverse effects and perhaps with adherence in the highest quartile of continuous leak profile. There was a need to change masks more often in patients with more continuous leaks.

Footnotes

  • Correspondence: Marcel A Baltzan MD DABSM, Mount Sinai Hospital Center, 5690 Cavendish Boulevard, Cote St-Luc (Montréal) Québec, Canada H4W 1S7. E-mail: marc.baltzan{at}clinepi.mcgill.ca.
  • This research was partly supported by the Mount Sinai Hospital Research Foundation and the OSR Médical Sleep Disorders Center.

  • The authors have disclosed no conflicts of interest.

  • Marcel A Baltzan MD DABSM presented a version of this paper at the 104th International Conference of the American Thoracic Society, held May 16-21, 2008, in Toronto, Ontario, Canada.

  • See the Related Editorial on Page 718

  • Copyright © 2011 by Daedalus Enterprises Inc.

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Respiratory Care: 56 (5)
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Leak Profile Inspection During Nasal Continuous Positive Airway Pressure
Marcel A Baltzan, Richard Dabrusin, Alfonso Garcia-Asensi, Jennie-Laure Sully, Maryse Parenteau, Germaine Tansimat, Ibrahim Kassissia, Norman Wolkove
Respiratory Care May 2011, 56 (5) 591-595; DOI: 10.4187/respcare.00977

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Leak Profile Inspection During Nasal Continuous Positive Airway Pressure
Marcel A Baltzan, Richard Dabrusin, Alfonso Garcia-Asensi, Jennie-Laure Sully, Maryse Parenteau, Germaine Tansimat, Ibrahim Kassissia, Norman Wolkove
Respiratory Care May 2011, 56 (5) 591-595; DOI: 10.4187/respcare.00977
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