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Research Article27th Annual New Horizons Symposium: Ventilator Liberation

Early Physical Rehabilitation in the ICU and Ventilator Liberation

Pedro A Mendez-Tellez and Dale M Needham
Respiratory Care October 2012, 57 (10) 1663-1669; DOI: https://doi.org/10.4187/respcare.01931
Pedro A Mendez-Tellez
Outcomes After Critical Illness and Surgery Group, Johns Hopkins University, Baltimore, Maryland.
Department of Anesthesiology and Critical Care Medicine;
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Dale M Needham
Outcomes After Critical Illness and Surgery Group, Johns Hopkins University, Baltimore, Maryland.
Division of Pulmonary and Critical Care Medicine, and the Department of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, Maryland.
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References

  1. 1.↵
    1. de Jonghe B,
    2. Sharshar T,
    3. Lefaucheur JP,
    4. Authier FJ,
    5. Durand-Zaleski I,
    6. Boussarsar M,
    7. et al
    ; Groupe de Réflexion et d'Etude des Neuromyopathies en Réanimation. Paresis acquired in the intensive care unit: a prospective multicenter study. JAMA 2002;288(22):2859–2867.
    OpenUrlCrossRefPubMedWeb of Science
  2. 2.
    1. Latronico N,
    2. Shehu I,
    3. Seghelini E
    . Neuromuscular sequelae of critical illness. Curr Opin Crit Care 2005;11(4):381–390.
    OpenUrlCrossRefPubMedWeb of Science
  3. 3.↵
    1. Stevens RD,
    2. Marshall SA,
    3. Cornblath DR,
    4. Hoke A,
    5. Needham DM,
    6. de Jonghe B,
    7. et al
    . A framework for diagnosing and classifying intensive care unit-acquired weakness. Crit Care Med 2009;37(10 Suppl):S299–S308.
    OpenUrlCrossRefPubMed
  4. 4.↵
    1. Ali NA,
    2. O'Brien JM Jr.,
    3. Hoffmann SP,
    4. Phillips G,
    5. Garland A,
    6. Finley JC,
    7. et al
    ; Midwest Critical Care Consortium. Acquired weakness, handgrip strength, and mortality in critically ill patients. Am J Respir Crit Care Med 2008;178(3):261–268.
    OpenUrlCrossRefPubMedWeb of Science
  5. 5.
    1. Sharshar T,
    2. Bastuji-Garin S,
    3. Stevens RD,
    4. Durand MC,
    5. Malissin I,
    6. Rodgriguez P,
    7. et al
    ; Groupe de Réflexion et d'Etude des Neuromyopathies en Réanimation. Presence and severity of intensive care unit-acquired paresis at time of awakening are associated with increased intensive care unit and hospital mortality. Crit Care Med 2009;37(12):3047–3053.
    OpenUrlCrossRefPubMedWeb of Science
  6. 6.
    1. Garnacho-Montero J,
    2. Madrazo-Osuna J,
    3. García-Garmendia JL,
    4. Ortiz-Leyba C,
    5. Jiménez-Jiménez FJ,
    6. Barrero-Almodóvar A,
    7. et al
    . Critical illness polyneuropathy: risk factors and clinical consequences. A cohort study in septic patients. Intensive Care Med 2001;27(8):1288–1296.
    OpenUrlCrossRefPubMedWeb of Science
  7. 7.
    1. Garnacho-Montero J,
    2. Amaya-Villar R,
    3. Garcia-Garmendia JL,
    4. Madrazo-Osuna J,
    5. Ortiz-Leyba C
    . Effect of critical illness polyneuropathy on the withdrawal from mechanical ventilation and the length of stay in septic patients. Crit Care Med 2005;33(2):349–354.
    OpenUrlCrossRefPubMedWeb of Science
  8. 8.↵
    1. de Jonghe B,
    2. Bastuji-Garin S,
    3. Sharshar T,
    4. Outin H,
    5. Brochard L
    . Does ICU-acquired paresis lengthen weaning from mechanical ventilation? Intensive Care Med 2004;30(6):1117–1121.
    OpenUrlCrossRefPubMedWeb of Science
  9. 9.↵
    1. Kollef MH,
    2. Levy NT,
    3. Ahrens TS,
    4. Schaiff R,
    5. Prentice D,
    6. Sherman G
    . The use of continuous iv sedation is associated with prolongation of mechanical ventilation. Chest 1998;114(2):541–548.
    OpenUrlCrossRefPubMedWeb of Science
  10. 10.
    1. Pandharipande P,
    2. Cotton BA,
    3. Shintani A,
    4. Thompson J,
    5. Pun BT,
    6. Morris JA Jr.,
    7. et al
    . Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients. J Trauma 2008;65(1):34–41.
    OpenUrlCrossRefPubMedWeb of Science
  11. 11.
    1. Agarwal V,
    2. O'Neill PJ,
    3. Cotton BA,
    4. Pun BT,
    5. Haney S,
    6. Thompson J,
    7. et al
    . Prevalence and risk factors for development of delirium in burn intensive care unit patients. J Burn Care Res 2010;31(5):706–715.
    OpenUrlCrossRefPubMed
  12. 12.↵
    1. Pandharipande P,
    2. Shintani A,
    3. Peterson J,
    4. Pun BT,
    5. Wilkinson GR,
    6. Dittus RS,
    7. et al
    . Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology 2006;104(1):21–26.
    OpenUrlCrossRefPubMedWeb of Science
  13. 13.↵
    1. Vassilakopoulos T,
    2. Petrof BJ
    . Ventilator-induced diaphragmatic dysfunction. Am J Respir Crit Care Med 2004;169(3):336–341.
    OpenUrlCrossRefPubMedWeb of Science
  14. 14.↵
    1. Laghi F,
    2. Cattapan SE,
    3. Jubran A,
    4. Parthasarathy S,
    5. Warshawsky P,
    6. Choi YS,
    7. Tobin MJ
    . Is weaning failure caused by low-frequency fatigue of the diaphragm? Am J Respir Crit Care Med 2003;167(2):120–127.
    OpenUrlCrossRefPubMedWeb of Science
  15. 15.↵
    1. Bailey P,
    2. Thomsen GE,
    3. Spuhler VJ,
    4. Blair R,
    5. Jewkes J,
    6. Bezdjian L,
    7. et al
    . Early activity is feasible and safe in respiratory failure patients. Crit Care Med 2007;35(1):139–145.
    OpenUrlCrossRefPubMedWeb of Science
  16. 16.↵
    1. Morris PE,
    2. Goad A,
    3. Thompson C,
    4. Taylor K,
    5. Harry B,
    6. Passmore L,
    7. et al
    . Early intensive care unit mobility therapy in the treatment of acute respiratory failure. Crit Care Med 2008;36(8):2238–2243.
    OpenUrlCrossRefPubMedWeb of Science
  17. 17.↵
    1. Schweickert WD,
    2. Pohlman MC,
    3. Pohlman AS,
    4. Nigos C,
    5. Pawlik AJ,
    6. Esbrook CL,
    7. et al
    . Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet 2009;373(9678):1874–1882.
    OpenUrlCrossRefPubMedWeb of Science
  18. 18.↵
    1. Burtin C,
    2. Clerckx B,
    3. Robbeets C,
    4. Ferdinande P,
    5. Langer D,
    6. Troosters T,
    7. et al
    . Early exercise in critically ill patients enhances short-term functional recovery. Crit Care Med 2009;37(9):2499–2505.
    OpenUrlCrossRefPubMedWeb of Science
  19. 19.↵
    1. Chiang L-L,
    2. Wang L-Y,
    3. Wu C-P,
    4. Wu H-D,
    5. Wu Y-T
    . Effects of physical training on functional status in patients with prolonged mechanical ventilation. Phys Ther 2006;86(9):1271–1281.
    OpenUrlAbstract/FREE Full Text
  20. 20.↵
    1. Martin UJ,
    2. Hincapie L,
    3. Nimchuk M,
    4. Gaughan J,
    5. Criner GJ
    . Impact of whole-body rehabilitation in patients receiving chronic mechanical ventilation. Crit Care Med 2005;33(10):2259–2265.
    OpenUrlCrossRefPubMedWeb of Science
  21. 21.↵
    1. Paddon-Jones D,
    2. Sheffield-Moore M,
    3. Urban RJ,
    4. Sanford AP,
    5. Aarsland A,
    6. Wolfe RR,
    7. Ferrando AA
    . Essential amino acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest. J Clin Endocrinol Metab 2004;89(9):4351–4358.
    OpenUrlCrossRefPubMedWeb of Science
  22. 22.↵
    1. Powers SK,
    2. Smuder AJ,
    3. Criswell DS
    . Mechanistic links between oxidative stress and disuse muscle atrophy. Antioxid Redox Signal 2011;15(9):2519–2528.
    OpenUrlCrossRefPubMedWeb of Science
  23. 23.↵
    1. Phillips SM,
    2. Glover EI,
    3. Rennie MJ
    . Alterations of protein turnover underlying disuse atrophy in human skeletal muscle. J Appl Physiol 2009;107(3):645–654.
    OpenUrlAbstract/FREE Full Text
  24. 24.↵
    1. Monk DN,
    2. Plank LD,
    3. Franch-Arcas G,
    4. Finn PJ,
    5. Streat SJ,
    6. Hill GL
    . Sequential changes in the metabolic response in critically injured patients during the first 25 days after blunt trauma. Ann Surg 1996;223(4):395–405.
    OpenUrlCrossRefPubMedWeb of Science
  25. 25.↵
    1. Plank LD,
    2. Connolly a B,
    3. Hill GL
    . Sequential changes in the metabolic response in severely septic patients during the first 23 days after the onset of peritonitis. Ann Surg 1998;228(2):146–158.
    OpenUrlCrossRefPubMedWeb of Science
  26. 26.↵
    1. Finn P,
    2. Plank L,
    3. Clark M,
    4. Connolly A
    . Progressive cellular dehydration and proteolysis in critically ill patients. Lancet 1996;347(9002):654–656.
    OpenUrlCrossRefPubMedWeb of Science
  27. 27.↵
    1. Griffiths RD
    . Muscle mass, survival, and the elderly ICU patient. Nutrition 1996;12(6):456–458.
    OpenUrlCrossRefPubMedWeb of Science
  28. 28.↵
    1. Derde S,
    2. Hermans G,
    3. Derese I,
    4. Güiza F,
    5. Hedström Y,
    6. Wouters PJ,
    7. et al
    . Muscle atrophy and preferential loss of myosin in prolonged critically ill patients. Crit Care Med 2012;40(1):79–89.
    OpenUrlCrossRefPubMedWeb of Science
  29. 29.↵
    1. Ferrando AA,
    2. Lane HW,
    3. Stuart CA,
    4. Davis-Street J,
    5. Wolfe RR
    . Prolonged bed rest decreases skeletal muscle and whole body protein synthesis. Am J Physiol 1996;270(4 Pt 1):E627–E633.
    OpenUrlPubMedWeb of Science
  30. 30.↵
    1. Glover EI,
    2. Yasuda N,
    3. Tarnopolsky M a,
    4. Abadi A,
    5. Phillips SM
    . Little change in markers of protein breakdown and oxidative stress in humans in immobilization-induced skeletal muscle atrophy. Appl Physiol Nutr Metab 2010;35(2):125–133.
    OpenUrlCrossRefPubMedWeb of Science
  31. 31.↵
    1. Hussain SN,
    2. Mofarrahi M,
    3. Sigala I,
    4. Kim HC,
    5. Vassilakoopoulos T,
    6. Maltais F,
    7. et al
    . Mechanical ventilation-induced diaphragm disuse in humans triggers autophagy. Am J Respir Crit Care Med 2010;182(11):1377–1386.
    OpenUrlCrossRefPubMedWeb of Science
  32. 32.
    1. Levine S,
    2. Biswas C,
    3. Dierov J,
    4. Barsotti R,
    5. Shrager JB,
    6. Nguyen T,
    7. et al
    . Increased proteolysis, myosin depletion, and atrophic AKT-FOXO signaling in human diaphragm disuse. Am J Respir Crit Care Med 2011;183(4):483–490.
    OpenUrlCrossRefPubMedWeb of Science
  33. 33.↵
    1. Tesch PA,
    2. von Walden F,
    3. Gustafsson T,
    4. Linnehan RM,
    5. Trappe TA
    . Skeletal muscle proteolysis in response to short-term unloading in humans. J Appl Physiol 2008;105(3):902–906.
    OpenUrlAbstract/FREE Full Text
  34. 34.↵
    1. Powers SK,
    2. Kavazis AN,
    3. DeRuisseau KC
    . Mechanisms of disuse muscle atrophy: role of oxidative stress. Am J Physiol Regul Integr Comp Physiol 2005;288(2):R337–R344.
    OpenUrlAbstract/FREE Full Text
  35. 35.↵
    1. Chambers MA,
    2. Moylan JS,
    3. Reid MB
    . Physical inactivity and muscle weakness in the critically ill. Crit Care Med 2009;37(10 Suppl):S337–S346.
    OpenUrlCrossRefPubMed
  36. 36.↵
    1. Powers S,
    2. Kavazis A,
    3. McClung J
    . Oxidative stress and disuse muscle atrophy. J Appl Physiol 2007;102(6):2389–2397.
    OpenUrlAbstract/FREE Full Text
  37. 37.↵
    1. Powers SK,
    2. Kavazis AN,
    3. Levine S
    . Prolonged mechanical ventilation alters diaphragmatic structure and function. Crit Care Med 2009;37(10 Suppl):S347–S353.
    OpenUrlCrossRefPubMed
  38. 38.↵
    1. Hudson MB,
    2. Smuder AJ,
    3. Nelson WB,
    4. Bruells CS,
    5. Levine S,
    6. Powers SK
    . Both high level pressure support ventilation and controlled mechanical ventilation induce diaphragm dysfunction and atrophy. Crit Care Med 2012;40(4):1254–1260.
    OpenUrlCrossRefPubMedWeb of Science
  39. 39.↵
    1. McClung JM,
    2. Kavazis AN,
    3. DeRuisseau KC,
    4. Falk DJ,
    5. Deering MA,
    6. Lee Y,
    7. et al
    . Caspase-3 regulation of diaphragm myonuclear domain during mechanical ventilation-induced atrophy. Am J Respir Crit Care Med 2007;175(2):150–159.
    OpenUrlCrossRefPubMedWeb of Science
  40. 40.↵
    1. Shanely RA,
    2. Zergeroglu MA,
    3. Lennon SL,
    4. Sugiura T,
    5. Yimlamai T,
    6. Enns D,
    7. et al
    . Mechanical ventilation-induced diaphragmatic atrophy is associated with oxidative injury and increased proteolytic activity. Am J Respir Crit Care Med 2002;166(10):1369–1374.
    OpenUrlCrossRefPubMedWeb of Science
  41. 41.↵
    1. Levine S,
    2. Nguyen T,
    3. Taylor N,
    4. Friscia ME,
    5. Budak MT,
    6. Rothenberg P,
    7. et al
    . Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans. N Engl J Med 2008;358(13):1327–1335.
    OpenUrlCrossRefPubMedWeb of Science
  42. 42.↵
    1. Sassoon CSH,
    2. Caiozzo VJ,
    3. Manka A,
    4. Sieck GC
    . Altered diaphragm contractile properties with controlled mechanical ventilation. J Appl Physiol 2002;92(6):2585–2595.
    OpenUrlAbstract/FREE Full Text
  43. 43.↵
    1. Bernard N,
    2. Matecki S,
    3. Py G,
    4. Lopez S,
    5. Mercier J,
    6. Capdevila X
    . Effects of prolonged mechanical ventilation on respiratory muscle ultrastructure and mitochondrial respiration in rabbits. Intensive Care Med 2003;29(1):111–118.
    OpenUrlPubMedWeb of Science
  44. 44.↵
    1. Shanely RA,
    2. Van Gammeren D,
    3. Deruisseau KC,
    4. Deruisseau KC,
    5. Zergeroglu AM,
    6. McKenzie MJ,
    7. et al
    . Mechanical ventilation depresses protein synthesis in the rat diaphragm. Am J Respir Crit Care Med 2004;170(9):994–999.
    OpenUrlCrossRefPubMedWeb of Science
  45. 45.↵
    1. Falk DJ,
    2. Deruisseau KC,
    3. Van Gammeren DL,
    4. Deering MA,
    5. Kavazis AN,
    6. Powers SK
    . Mechanical ventilation promotes redox status alterations in the diaphragm. J Appl Physiol 2006;101(4):1017–1024.
    OpenUrlAbstract/FREE Full Text
  46. 46.↵
    1. DeRuisseau KC,
    2. Shanely RA,
    3. Akunuri N,
    4. Hamilton MT,
    5. Van Gammeren D,
    6. Zergeroglu AM,
    7. et al
    . Diaphragm unloading via controlled mechanical ventilation alters the gene expression profile. Am J Respir Crit Care Med 2005;172(10):1267–1275.
    OpenUrlCrossRefPubMedWeb of Science
  47. 47.↵
    1. Gosselink R,
    2. Bott J,
    3. Johnson M,
    4. Dean E,
    5. Nava S,
    6. Norrenberg,
    7. et al
    . Physiotherapy for adult patients with critical illness: recommendations of the European Respiratory Society and European Society of Intensive Care Medicine Task Force on Physiotherapy for Critically Ill Patients. Intensive Care Med 2008;34(7):1188–1199.
    OpenUrlCrossRefPubMedWeb of Science
  48. 48.↵
    1. Pronovost P,
    2. Berenholtz S,
    3. Needham D
    . Translating evidence into practice: a model for large scale knowledge translation (abstract). BMJ 2008;337:a1714.
    OpenUrlFREE Full Text
  49. 49.↵
    1. Needham DM,
    2. Korupolu R,
    3. Zanni JM,
    4. Pradhan P,
    5. Colantuoni E,
    6. Palmer JB,
    7. et al
    . Early physical medicine and rehabilitation for patients with acute respiratory failure: a quality improvement project. Arch Phys Med Rehabil 2010;91(4):536–542.
    OpenUrlCrossRefPubMedWeb of Science
  50. 50.↵
    1. Needham DM,
    2. Korupolu R
    . Rehabilitation quality improvement in an intensive care unit setting: implementation of a quality improvement model. Top Stroke Rehab 2010;17(4):271–281.
    OpenUrlCrossRef
  51. 51.↵
    1. Korupolu R,
    2. Gifford J,
    3. Needham D
    . Early mobilization of critically ill patients: reducing neuromuscular complications after intensive care. Contemp Crit Care 2009;6(9):1–11.
    OpenUrl
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1 Oct 2012
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Early Physical Rehabilitation in the ICU and Ventilator Liberation
Pedro A Mendez-Tellez, Dale M Needham
Respiratory Care Oct 2012, 57 (10) 1663-1669; DOI: 10.4187/respcare.01931

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Early Physical Rehabilitation in the ICU and Ventilator Liberation
Pedro A Mendez-Tellez, Dale M Needham
Respiratory Care Oct 2012, 57 (10) 1663-1669; DOI: 10.4187/respcare.01931
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  • Article
    • Abstract
    • Introduction
    • Physical Inactivity and Skeletal Muscle Weakness
    • Mechanical Ventilation and Diaphragmatic Weakness
    • Early Physical Rehabilitation of Mechanically Ventilated Patients
    • Initiating an Early Physical Rehabilitation Program for Mechanically Ventilated Patients
    • Conclusions
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • References
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Cited By...

Keywords

  • physical therapy
  • mechanical ventilation
  • muscle atrophy
  • muscle weakness
  • intensive care
  • ICU
  • rehabilitation

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