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Research ArticleOriginal Research

Isoflurane for Life-Threatening Bronchospasm: A 15-Year Single-Center Experience

David A Turner, David Heitz, Mehrengise K Cooper, P Brian Smith, John H Arnold and Scot T Bateman
Respiratory Care November 2012, 57 (11) 1857-1864; DOI: https://doi.org/10.4187/respcare.01605
David A Turner
Division of Pediatric Critical Care Medicine, Department of Pediatrics, Duke Children's Hospital, Duke University Medical Center, Durham, North Carolina.
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  • For correspondence: [email protected]
David Heitz
Respiratory Care Services, Children's Hospital of Atlanta, Atlanta, Georgia.
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Mehrengise K Cooper
Paediatrics Services, Saint Mary's Hospital, Imperial College Healthcare National Health Service Trust, London, United Kingdom.
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P Brian Smith
Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina.
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John H Arnold
Department of Anesthesia (Pediatrics), Children's Hospital, Boston, Massachusetts.
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Scot T Bateman
Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Massachusetts Memorial Medical Center, Worcester, Massachusetts.
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    Fig. 1.

    This figure demonstrates the pH change during isoflurane administration. This figure compares pH values at baseline (prior to isoflurane initiation) 4 hours, 24 hours, and the time of isoflurane discontinuation. The plots represent the median (line), interquartile range (box), and adjacent values (whiskers). * P = < .001 at 4 hours, compared to baseline. † P = < .001 at 24 hours, compared to 4 hours. ‡ P = < .001 at end of therapy, compared to 24 hours.

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    Fig. 2.

    This figure demonstrates the PCO2 change during isoflurane administration. This figure compares PCO2 values at baseline (prior to isoflurane initiation), 4 hours, 24 hours, and the time of isoflurane discontinuation. The plots represent the median (line), interquartile range (box), and adjacent values (whiskers). * P = < .001 at 4 hours, compared to baseline.

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Respiratory Care: 57 (11)
Respiratory Care
Vol. 57, Issue 11
1 Nov 2012
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Isoflurane for Life-Threatening Bronchospasm: A 15-Year Single-Center Experience
David A Turner, David Heitz, Mehrengise K Cooper, P Brian Smith, John H Arnold, Scot T Bateman
Respiratory Care Nov 2012, 57 (11) 1857-1864; DOI: 10.4187/respcare.01605

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Isoflurane for Life-Threatening Bronchospasm: A 15-Year Single-Center Experience
David A Turner, David Heitz, Mehrengise K Cooper, P Brian Smith, John H Arnold, Scot T Bateman
Respiratory Care Nov 2012, 57 (11) 1857-1864; DOI: 10.4187/respcare.01605
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Keywords

  • asthma
  • bronchospasm
  • mechanical ventilation
  • inhaled anesthetics
  • isoflurane
  • pediatric ICU

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