Practice of Excessive FIO2 and Effect on Pulmonary Outcomes in Mechanically Ventilated Patients With Acute Lung Injury

Sonal Rachmale; Guangxi Li; Gregory Wilson; Michael Malinchoc; Ognjen Gajic

doi:10.4187/respcare.01696

Research ArticleOriginal Research

Practice of Excessive F_IO₂ and Effect on Pulmonary Outcomes in Mechanically Ventilated Patients With Acute Lung Injury

Sonal Rachmale, Guangxi Li, Gregory Wilson, Michael Malinchoc and Ognjen Gajic

Respiratory Care November 2012, 57 (11) 1887-1893; DOI: https://doi.org/10.4187/respcare.01696

Sonal Rachmale

Mayo Epidemiology and Translational Research in Intensive Care program, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota.

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For correspondence: [email protected]

Guangxi Li

Mayo Epidemiology and Translational Research in Intensive Care program, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota.

Division of Pulmonary Medicine, Department of Medicine, Guang'anmen Hospital, China Academy of Chinese Medical Science, Beijing, China.

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Gregory Wilson

Division of Respiratory Therapy, Anesthesia Clinical Research; and

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Michael Malinchoc

Department of Biostatistics, Mayo Clinic, Rochester, Minnesota.

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Ognjen Gajic

Mayo Epidemiology and Translational Research in Intensive Care program, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota.

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Fig. 1.
F_IO₂, S_pO₂, and PEEP in an example patient.
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Fig. 2.
Outline of the study. MV = mechanical ventilation.
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Fig. 3.
Change in oxygenation index from initiation of mechanical ventilation (baseline) to 48 h after intubation, versus F_IO₂.
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Fig. 4.
Mean worsening of oxygenation index 48 h after initiation of mechanical ventilation (baseline), versus hours of excessive F_IO₂.

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Respiratory Care

Vol. 57, Issue 11

1 Nov 2012

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Practice of Excessive F_IO₂ and Effect on Pulmonary Outcomes in Mechanically Ventilated Patients With Acute Lung Injury