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Research ArticleOriginal Research

Practice of Excessive FIO2 and Effect on Pulmonary Outcomes in Mechanically Ventilated Patients With Acute Lung Injury

Sonal Rachmale, Guangxi Li, Gregory Wilson, Michael Malinchoc and Ognjen Gajic
Respiratory Care November 2012, 57 (11) 1887-1893; DOI: https://doi.org/10.4187/respcare.01696
Sonal Rachmale
Mayo Epidemiology and Translational Research in Intensive Care program, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota.
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  • For correspondence: [email protected]
Guangxi Li
Mayo Epidemiology and Translational Research in Intensive Care program, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota.
Division of Pulmonary Medicine, Department of Medicine, Guang'anmen Hospital, China Academy of Chinese Medical Science, Beijing, China.
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Gregory Wilson
Division of Respiratory Therapy, Anesthesia Clinical Research; and
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Michael Malinchoc
Department of Biostatistics, Mayo Clinic, Rochester, Minnesota.
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Ognjen Gajic
Mayo Epidemiology and Translational Research in Intensive Care program, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota.
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    Fig. 1.

    FIO2, SpO2, and PEEP in an example patient.

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    Fig. 2.

    Outline of the study. MV = mechanical ventilation.

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    Fig. 3.

    Change in oxygenation index from initiation of mechanical ventilation (baseline) to 48 h after intubation, versus FIO2.

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    Fig. 4.

    Mean worsening of oxygenation index 48 h after initiation of mechanical ventilation (baseline), versus hours of excessive FIO2.

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Respiratory Care: 57 (11)
Respiratory Care
Vol. 57, Issue 11
1 Nov 2012
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Practice of Excessive FIO2 and Effect on Pulmonary Outcomes in Mechanically Ventilated Patients With Acute Lung Injury
Sonal Rachmale, Guangxi Li, Gregory Wilson, Michael Malinchoc, Ognjen Gajic
Respiratory Care Nov 2012, 57 (11) 1887-1893; DOI: 10.4187/respcare.01696

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Practice of Excessive FIO2 and Effect on Pulmonary Outcomes in Mechanically Ventilated Patients With Acute Lung Injury
Sonal Rachmale, Guangxi Li, Gregory Wilson, Michael Malinchoc, Ognjen Gajic
Respiratory Care Nov 2012, 57 (11) 1887-1893; DOI: 10.4187/respcare.01696
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Keywords

  • oxygen
  • hyperoxia
  • acute lung injury
  • mechanical ventilation
  • ICU

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