In the paper, “MicroRNA Expression Profile in Hyperoxia-Exposed Newborn Mice During the Development of Bronchopulmonary Dysplasia” by Xiaoying Zhang, Wei Peng, Sheng Zhang, Chunzhi Wang, Xiyu He, Zhimei Zhang, et al, [Respir Care 2011 56(7):1009–1015; doi:10.4187/respcare.01032], the authors correct errors in the methods and results. The naming of the microRNAs was incorrect in the following text and in Figures 4 and 5. The correct text and figures are below. This correction does not alter the conclusions of the paper.
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Conversely, on day 2 the levels of miR-299, miR-139-3p, miR-300 star, and miR-122; on day 7 the levels of miR-335-5p and miR-714; and on day 21 the level of miR-720 were more than 2-fold lower in the BPD mice (Fig. 4A-C).
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We analyzed the proliferation potential of cells (A549) transfected with microRNAs (hsa-let-7f, hsa-miR-29a, hsa-miR-21, hsa-miR-20b, hsa-miR-127, and hsa-miR-431) or miR-mock. The results revealed that overexpression of miR-21 or −20b induced cell proliferation significantly (P = .02 and P = .007, respectively), whereas miR-29a, −127, −431, and let-7f significantly reduced cell proliferation (P = .003, P = .03, P = .006 and P = .006, respectively), compared to miR-mock (Fig. 5).
However, 14 microRNAs (miR-20b, miR-106a, miR-128, miR-883b-3p, miR-15b, miR-122, miR-30e, miR-365–5p, miR-133a, miR-205, miR-379, miR-449a, miR-431, and let-7f) were greatly up-regulated in the BPD lungs, compared to the control lungs, whereas 7 microRNAs (miR-299, miR-139-3p, miR-300 star, miR-122, miR-335-5p, miR-714, and miR-720) were significantly down-regulated in the BPD lungs, compared to the control lungs, some of which could regulate cell proliferation.
4A, x-axis, should be miR-139-3p, not miR-139p-3p
4B, x-axis, should be miR-335-5p, not miR-335b-5p
x-axis, should be miR-431, not miR-134
The corrected figures are on next page.
Differential expression of microRNAs in a control group and a hyperoxia group of neonatal mice. A: Day 2. B: Day 7. C: Day 21. The dotted lines represent a 2-fold change in expression.
Candidate microRNAs that significantly affected cell proliferation, as assessed via XTT (2–3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenylamino) carbonyl]-2H-tetrazolium hydroxide) 48 hours after transfection, compared to miR-mock. The whisker bars indicate standard deviations.
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