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Research ArticleEditor's Choice

Albuterol Delivery by 4 Different Nebulizers Placed in 4 Different Positions in a Pediatric Ventilator In Vitro Model

Ariel Berlinski and J Randy Willis
Respiratory Care July 2013, 58 (7) 1124-1133; DOI: https://doi.org/10.4187/respcare.02074
Ariel Berlinski
Arkansas Children's Hospital, Little Rock, Arkansas.
Pulmonology Section, Department of Pediatrics, University of Arkansas for Medical Sciences, and with the Pediatric Aerosol Research Laboratory, Arkansas Children's Hospital Research Institute, Little Rock, Arkansas
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  • For correspondence: [email protected]
J Randy Willis
Arkansas Children's Hospital, Little Rock, Arkansas.
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  • Fig. 1.
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    Fig. 1.

    Nebulizers tested. From right to left: Aerogen Solo, Maquet Ultrasonic model N06302595E400E, Salter 8900, and Hudson Updraft II Opti-Neb.

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    Fig. 2.

    Testing set-up. Position A: At the ventilator on the inspiratory side. Position B: Between the humidifier and the inspiratory limb. Position C: Between the inspiratory limb and the Y-piece. Position D: In the inspiratory limb, 30 cm before the Y-piece. ETT = endotracheal tube.

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    Fig. 3.

    Intra-device comparison of albuterol captured at the end of the endotracheal tube (lung dose). With the Updraft II Opti-Neb jet nebulizer, lung dose with the 2.5 mg/3 mL solution when placed at the Y-piece was lower than all, and lung dose with the 5.0 mg/3.5 mL and 7.5 mg/4 mL solutions when positioned at the ventilator was similar to humidifier and was greater than at the Y-piece and 30 cm from the Y-piece. With the Salter 8900 jet nebulizer, lung dose with the 2.5 mg/3 mL solution when placed at the humidifier was greater than all other positions, and lung dose with the 5.0 mg/3.5 mL and 7.5 mg/4 mL solutions when positioned at the ventilator was similar to humidifier and was greater than Y-piece and 30 cm from the Y-piece. With the Maquet ultrasonic nebulizer, lung dose with the 2.5 mg/3 mL solution when placed at the humidifier was greater than all other positions, and also lung dose was greater at the ventilator than at the Y-piece; output with the 5.0 mg/3.5 mL solution when placed at the humidifier was greater than the Y-piece and 30 cm from the Y-piece and lung dose was greater at the ventilator than at the Y-piece; lung dose with the 7.5 mg/4 mL solution when placed at the humidifier was greater than all other positions, and lung dose was greater at the ventilator than at the Y-piece and 30 cm from the Y-piece. With the Aerogen Solo vibrating mesh nebulizer, lung dose with all solutions tested when positioned at the ventilator was similar to humidifier and was greater than Y-piece and 30 cm from the Y-piece.

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    Fig. 4.

    Inter-device comparison. * Deposition with the Aerogen Solo vibrating mesh nebulizer was greater than with all other nebulizers (P < .01). † Deposition with the Maquet ultrasonic nebulizer was greater than with the Salter 8900 nebulizer (P < .05). ‡ Deposition with the Maquet ultrasonic nebulizer was greater than with the Hudson Updraft II Opti-Neb nebulizer (P < .05). § Deposition with the Aerogen Solo vibrating mesh nebulizer was greater than with the Hudson Updraft II Opti-Neb and Salter 8900 nebulizers (P < .01).

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Respiratory Care: 58 (7)
Respiratory Care
Vol. 58, Issue 7
1 Jul 2013
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Albuterol Delivery by 4 Different Nebulizers Placed in 4 Different Positions in a Pediatric Ventilator In Vitro Model
Ariel Berlinski, J Randy Willis
Respiratory Care Jul 2013, 58 (7) 1124-1133; DOI: 10.4187/respcare.02074

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Albuterol Delivery by 4 Different Nebulizers Placed in 4 Different Positions in a Pediatric Ventilator In Vitro Model
Ariel Berlinski, J Randy Willis
Respiratory Care Jul 2013, 58 (7) 1124-1133; DOI: 10.4187/respcare.02074
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Keywords

  • Mechanical ventilation
  • albuterol
  • jet nebulizer
  • vibrating mesh nebulizer
  • ultrasonic nebulizer
  • position
  • pediatrics
  • aerosol
  • humidifier

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