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Research ArticleOriginal Research

Experimental Model of Atelectasis in Newborn Piglets

Talitha Comaru, Humberto Holmer Fiori, Renato Machado Fiori, Priscila Padoim, Jaqueline Basso Stivanin and Vinicius Duval da Silva
Respiratory Care January 2014, 59 (1) 121-126; DOI: https://doi.org/10.4187/respcare.02352
Talitha Comaru
Postgraduate Program in Medicine–Pediatrics and Child Health
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Humberto Holmer Fiori
Department of Pediatrics
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Renato Machado Fiori
Department of Pediatrics
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  • For correspondence: [email protected]
Priscila Padoim
Postgraduate Program in Medicine–Pediatrics and Child Health
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Jaqueline Basso Stivanin
Postgraduate Program in Medicine–Pediatrics and Child Health
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Vinicius Duval da Silva
Department of Pathology, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
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    Fig. 1.

    Flow chart.

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    Fig. 2.

    Radiographs of a newborn piglet before (left) and after (right) injection of artificial mucus, which produced atelectasis in 10 of 13 piglets.

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    Fig. 3.

    PaO2 before, immediately after, and 30 min after injection of artificial mucus in newborn piglets. Responders P = .01, non-responders P = .29, via Wilcoxon signed-rank test. In each data bar the horizontal line represents the median, the top and bottom of the bar represent the IQR, the whisker bars represent the 25th and 75th percentiles, and the dots represent outliers.

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    Fig. 4.

    Histology sections of a representative sample of the lower lobe of a newborn piglet that received only mechanical ventilation (left) and one that received mechanical ventilation and injection of artificial mucus (right). Magnification 50×.

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    Fig. 5.

    Histology section of a representative sample of the right lower lobe of a newborn piglet after injection of artificial mucus. Magnification 50×.

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Respiratory Care: 59 (1)
Respiratory Care
Vol. 59, Issue 1
1 Jan 2014
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Experimental Model of Atelectasis in Newborn Piglets
Talitha Comaru, Humberto Holmer Fiori, Renato Machado Fiori, Priscila Padoim, Jaqueline Basso Stivanin, Vinicius Duval da Silva
Respiratory Care Jan 2014, 59 (1) 121-126; DOI: 10.4187/respcare.02352

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Experimental Model of Atelectasis in Newborn Piglets
Talitha Comaru, Humberto Holmer Fiori, Renato Machado Fiori, Priscila Padoim, Jaqueline Basso Stivanin, Vinicius Duval da Silva
Respiratory Care Jan 2014, 59 (1) 121-126; DOI: 10.4187/respcare.02352
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Keywords

  • atelectasis
  • animal model
  • mechanical ventilation
  • newborn
  • mucus
  • Physiotherapy
  • Swine

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