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Research ArticleOriginal Research

New Generation Neonatal High Frequency Ventilators: Effect of Oscillatory Frequency and Working Principles on Performance

Serge Grazioli, Oliver Karam and Peter C Rimensberger
Respiratory Care March 2015, 60 (3) 363-370; DOI: https://doi.org/10.4187/respcare.03048
Serge Grazioli
Neonatal and Pediatric Intensive Care Unit, University Hospital of Geneva, Switzerland.
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Oliver Karam
Neonatal and Pediatric Intensive Care Unit, University Hospital of Geneva, Switzerland.
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Peter C Rimensberger
Neonatal and Pediatric Intensive Care Unit, University Hospital of Geneva, Switzerland.
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    Fig. 1.

    Diagram of the experimental setup of the test lung. P/V̇-sensor = pressure/flow sensor.

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    Fig. 2.

    Delivered tidal volume (VT) with various pressure amplitudes and oscillation frequencies in A: full-term infant settings and B: pre-term infant settings. Five ventilators were compared: Babylog VN500, Fabian HFO, Leoni Plus, SensorMedics, and SLE 5000, using the same mean airway pressure setting of 15 cm H2O and I:E of 1:1. Note that, at a frequency of 15 Hz under full-term infant settings, the Babylog VN500 was not able to increase the pressure amplitude beyond 36 cm H2O (white marker); under pre-term infant settings, the maximal pressure amplitudes delivered by the Babylog VN500 at 10 Hz and 15 Hz were 55 cm H2O and 33 cm H2O, respectively (white markers).

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    Fig. 3.

    Tidal volume (VT) responses to change in oscillation frequencies, lung compliance, and resistance after activation of the volume-targeted mode in A: full-term and B: pre-term infant settings. Three ventilators were compared: Babylog VN500, Fabian HFO, and the Leoni Plus, using the same mean airway pressure setting of 15 cm H2O, I:E of 1:1, and the maximal setting for oscillatory pressure limitation. The VT target was set at 4 mL under full-term infant settings and 1 mL under pre-term infant settings. C = compliance; R = resistance

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Respiratory Care: 60 (3)
Respiratory Care
Vol. 60, Issue 3
1 Mar 2015
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New Generation Neonatal High Frequency Ventilators: Effect of Oscillatory Frequency and Working Principles on Performance
Serge Grazioli, Oliver Karam, Peter C Rimensberger
Respiratory Care Mar 2015, 60 (3) 363-370; DOI: 10.4187/respcare.03048

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New Generation Neonatal High Frequency Ventilators: Effect of Oscillatory Frequency and Working Principles on Performance
Serge Grazioli, Oliver Karam, Peter C Rimensberger
Respiratory Care Mar 2015, 60 (3) 363-370; DOI: 10.4187/respcare.03048
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Keywords

  • high frequency ventilation
  • neonatal intensive care
  • respiratory mechanics
  • volume-targeted ventilation

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